Cemek Mustafa, Caksen Hüseyin, Bayiroğlu Fahri, Cemek Fatma, Dede Semiha
Department of Chemistry (Biochemistry Division), Faculty of Science, Afyon Kocatepe University, Afyon, Turkey.
Cell Biochem Funct. 2006 May-Jun;24(3):269-73. doi: 10.1002/cbf.1220.
In this article, oxidative stress and enzymic-non-enzymic antioxidants status were investigated in children with acute pneumonia. Our study included 28 children with acute pneumonia and 29 control subjects. The age ranged from 2 to 11 years (4.57+/-2.13 years) and 2 to 12 years (4.89+/-2.22 years) in the study and control groups, respectively. Whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin C, vitamin E, catalase (CAT), ceruloplasmin (CLP), total bilirubin, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were studied in all subjects. There was a statistically significant difference between the groups for all parameters except for serum CAT. Whole blood MDA, serum CLP and total bilirubin levels were higher in the study group than those of the control group. However, SOD, GPx, beta-carotene, retinol, vitamin C, vitamin E and GSH levels were lower in the study group compared with the control group. All antioxidant vitamin activities were decreased in children with acute pneumonia. Our study demonstrated that oxidative stress was increased whereas enzymic and non-enzymic antioxidant activities were significantly decreased in children with acute pneumonia.
在本文中，我们对急性肺炎患儿的氧化应激及酶促-非酶促抗氧化剂状态进行了研究。我们的研究纳入了28例急性肺炎患儿和29例对照受试者。研究组和对照组的年龄分别为2至11岁（4.57±2.13岁）和2至12岁（4.89±2.22岁）。对所有受试者的全血丙二醛（MDA）、还原型谷胱甘肽（GSH）、血清β-胡萝卜素、视黄醇、维生素C、维生素E、过氧化氢酶（CAT）、铜蓝蛋白（CLP）、总胆红素、红细胞超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）水平进行了研究。除血清CAT外，两组所有参数均存在统计学显著差异。研究组的全血MDA、血清CLP和总胆红素水平高于对照组。然而，研究组的SOD、GPx、β-胡萝卜素、视黄醇、维生素C、维生素E和GSH水平低于对照组。急性肺炎患儿的所有抗氧化维生素活性均降低。我们的研究表明，急性肺炎患儿的氧化应激增加，而酶促和非酶促抗氧化活性显著降低。
