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创伤后应激障碍相关的儿童期虐待的治疗:一项随机对照试验。

Treatment for PTSD related to childhood abuse: a randomized controlled trial.

机构信息

Department of Child and Adolescent Psychiatry, New York University School of Medicine, 215 Lexington Ave., New York, NY 10016, USA.

出版信息

Am J Psychiatry. 2010 Aug;167(8):915-24. doi: 10.1176/appi.ajp.2010.09081247. Epub 2010 Jul 1.

Abstract

OBJECTIVE

Posttraumatic stress disorder (PTSD) related to childhood abuse is associated with features of affect regulation and interpersonal disturbances that substantially contribute to impairment. Existing treatments do not address these problems or the difficulties they may pose in the exploration of trauma memories, an efficacious and frequently recommended approach to resolving PTSD. The authors evaluated the benefits and risks of a treatment combining an initial preparatory phase of skills training in affect and interpersonal regulation (STAIR) followed by exposure by comparing it against two control conditions: Supportive Counseling followed by Exposure (Support/Exposure) and skills training followed by Supportive Counseling (STAIR/Support).

METHOD

Participants were women with PTSD related to childhood abuse (N=104) who were randomly assigned to the STAIR/Exposure condition, Support/Exposure condition (exposure comparator), or STAIR/Support condition (skills comparator) and assessed at posttreatment, 3 months, and 6 months.

RESULTS

The STAIR/Exposure group was more likely to achieve sustained and full PTSD remission relative to the exposure comparator, while the skills comparator condition fell in the middle (27% versus 13% versus 0%). STAIR/Exposure produced greater improvements in emotion regulation than the exposure comparator and greater improvements in interpersonal problems than both conditions. The STAIR/Exposure dropout rate was lower than the rate for the exposure comparator and similar to the rate for the skills comparator. There were significantly lower session-to-session PTSD symptoms during the exposure phase in the STAIR/Exposure condition than in the Support/Exposure condition. STAIR/Exposure was associated with fewer cases of PTSD worsening relative to both of the other two conditions.

CONCLUSIONS

For a PTSD population with chronic and early-life trauma, a phase-based skills-to-exposure treatment was associated with greater benefits and fewer adverse effects than treatments that excluded either skills training or exposure.

摘要

目的

与儿童期虐待相关的创伤后应激障碍(PTSD)与情绪调节和人际障碍有关,这些问题严重影响了患者的功能。现有的治疗方法并未解决这些问题,也未解决在探索创伤记忆时可能出现的困难,而创伤记忆的探索是解决 PTSD 的一种有效且常被推荐的方法。作者评估了将技能培训(STAIR)与暴露相结合的治疗方法的益处和风险,该方法包括初始的情绪和人际关系调节技能培训准备阶段,然后进行暴露,将其与两种对照条件进行比较:支持性咨询后进行暴露(支持/暴露)和技能培训后进行支持性咨询(STAIR/支持)。

方法

参与者为与儿童期虐待相关的 PTSD 女性患者(N=104),她们被随机分配到 STAIR/暴露组、支持/暴露组(暴露对照组)或 STAIR/支持组(技能对照组),并在治疗后、3 个月和 6 个月进行评估。

结果

与暴露对照组相比,STAIR/暴露组更有可能实现持续和完全的 PTSD 缓解,而技能对照组则处于中间位置(27%对 13%对 0%)。STAIR/暴露组在情绪调节方面的改善程度优于暴露对照组,在人际关系问题方面的改善程度优于其他两组。STAIR/暴露组的脱落率低于暴露对照组,与技能对照组相似。与支持/暴露组相比,STAIR/暴露组在暴露阶段的 PTSD 症状在每个治疗阶段都显著降低。与其他两组相比,STAIR/暴露组 PTSD 恶化的病例更少。

结论

对于患有慢性和早期创伤的 PTSD 患者,基于阶段的技能-暴露治疗与仅进行技能培训或暴露治疗相比,具有更大的益处和更少的不良反应。

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