Nutritional Sciences, Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
J Am Coll Nutr. 2010 Feb;29(1):31-40. doi: 10.1080/07315724.2010.10719814.
To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome.
Randomized, controlled prospective trial.
General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC).
Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea.
Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR)-based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study.
Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 microM, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins.
Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients.
比较补充绿茶饮料或绿茶提取物与对照相比对体重、血糖和血脂谱、氧化应激生物标志物以及代谢综合征肥胖患者的安全性参数的影响。
随机、对照前瞻性试验。
俄克拉荷马大学健康科学中心（OUHSC）的一般临床研究中心（GCRC）。
招募了 35 名年龄和性别匹配的肥胖和代谢综合征患者，并将其随机分为对照组（4 杯水/天）、绿茶组（4 杯水/天）或绿茶提取物组（2 胶囊和 4 杯水/天），为期 8 周。茶和提取物组的表没食子儿茶素没食子酸酯（EGCG）剂量相似，这是绿茶中的一种活性化合物。
在筛选时以及在研究的第 4 和第 8 周时，分析人体测量学、血压、空腹血糖和血脂、基于核磁共振（NMR）的脂质颗粒大小、安全性参数、氧化应激生物标志物（氧化低密度脂蛋白[LDL]、髓过氧化物酶[MPO]、丙二醛和羟壬醛[MDA 和 HNE]）和游离儿茶素。
成对比较显示，绿茶饮料和绿茶提取物在 8 周时与对照组相比，体重和体重指数（BMI）明显下降（-2.5 +/- 0.7 公斤，p < 0.01，-1.9 +/- 0.6，p < 0.05）。绿茶饮料显示 LDL-胆固醇和 LDL/高密度脂蛋白（HDL）与对照组相比呈下降趋势（p < 0.1）。绿茶饮料还显著降低了 MDA 和 HNE（-0.39 +/- 0.06 microM，p < 0.0001）与对照组相比。在屏幕和第 8 周时，无论是饮料组还是提取物组都可以检测到游离儿茶素，这表明绿茶儿茶素的依从性和生物利用度。
绿茶饮料（4 杯水/天）或提取物（2 胶囊/天）的摄入 8 周可显著降低体重和 BMI。绿茶饮料进一步降低了脂质过氧化作用，与年龄和性别匹配的对照组相比，提示绿茶类黄酮在改善肥胖患者代谢综合征特征方面的作用。
