Department of Chemistry, Telik, Inc., Palo Alto, CA 94394, USA.
Cell Death Differ. 2010 Sep;17(9):1373-80. doi: 10.1038/cdd.2010.80. Epub 2010 Jul 2.
Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers engaged in the detoxification of xenobiotics. Recently, GSTs have also been shown to act as modulators of signal transduction pathways that control cell proliferation and cell death. Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets. This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation.
谷胱甘肽转移酶（GSTs）是一类能够催化谷胱甘肽（GSH）与多种亲电物质结合的酶。它们最广为人知的作用是作为细胞管家参与外来物质的解毒。最近，GSTs 也被证明能够作为信号转导途径的调节剂，控制细胞增殖和细胞死亡。它们参与癌细胞的生长和分化，以及对抗癌药物产生耐药性，这使它们成为有吸引力的药物靶点。这篇综述主要关注 GSTs 的抑制，特别是 GSTP1-1，作为治疗癌症和其他与异常细胞增殖相关疾病的潜在治疗方法。
