West Malcolm, Kiff Robert
Department of General Surgery, St. Helens and Knowsley Teaching Hospitals, Whiston Hospital NHS Trust, Warrington Rd, Whiston, Prescot L35 5DR, UK.
J Gastrointest Cancer. 2011 Sep;42(3):155-9. doi: 10.1007/s12029-010-9178-4.
There is an increasing evidence base to support the use of self-expanding metallic gastrointestinal stents. In patients with colorectal cancer, they are used as a bridge to surgery and for palliation. The purposes of this study are to assess technical success, clinical outcome, complication rate and patency following colonic stent insertion in patients with colonic cancer at a local level and to compare our results with the current evidence base.
A retrospective, two-centre study was conducted. Twenty-seven patients were included over a 5-year period. Six patients had undergone stent insertion as a bridge to surgery, and 21 had the procedure for palliation.
Initial technical success was achieved in 26 of 27 patients (96%). Of these 26 patients, clinical success was achieved in 24 patients (92%). Five patients (21%) suffered from stent re-occlusion, and one patient (4%) suffered from stent migration. There was one case (4%) of procedure-related perforation. Of the 19 palliative patients in whom clinical success was achieved, 17 (89%) were alive at 30 days, 13 (68%) at 90 (53%) days and 10 at 180 days. Average stent patency was 195 days.
WallFlex® self-expanding metallic gastrointestinal stents are a safe and effective means of alleviating obstructive symptoms in patients with colonic cancer requiring palliative treatment or as a bridge to surgery. Our data suggest that although a small percentage of patients are affected by stent re-occlusion, this does not contribute to premature mortality. They improve quality of life in palliative care patients as well as reducing premature morbidity and mortality caused by emergency surgery.
越来越多的证据支持使用自膨式金属胃肠道支架。在结直肠癌患者中,它们被用作手术的桥梁和姑息治疗手段。本研究的目的是在局部层面评估结肠癌患者结肠支架置入后的技术成功率、临床结果、并发症发生率和通畅率,并将我们的结果与当前的证据基础进行比较。
进行了一项回顾性、双中心研究。在5年期间纳入了27例患者。6例患者作为手术桥梁接受了支架置入,21例患者接受了姑息治疗。
27例患者中有26例(96%)初步获得技术成功。在这26例患者中,24例(92%)获得临床成功。5例患者(21%)发生支架再闭塞,1例患者(4%)发生支架移位。有1例(4%)与手术相关的穿孔。在19例获得临床成功的姑息治疗患者中,17例(89%)在30天时存活,13例(68%)在90天时存活,10例在180天时存活。平均支架通畅时间为195天。
WallFlex®自膨式金属胃肠道支架是缓解需要姑息治疗或作为手术桥梁的结肠癌患者梗阻症状的一种安全有效的手段。我们的数据表明,尽管一小部分患者受到支架再闭塞的影响,但这并不导致过早死亡。它们改善了姑息治疗患者的生活质量,同时降低了急诊手术导致的过早发病率和死亡率。