Department of Urology, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Urology. 2011 Jan;77(1):183-6. doi: 10.1016/j.urology.2010.04.048.
To assess the relationship between nocturia and depression, two inflammatory conditions that affect a significant number of men worldwide.
We asked 547 male patients to self-administer the American Urological Association Symptom Score (AUA-SS) and the Geriatric Depression Scale (GDS), a validated screening tool for depression. Univariate analysis identified significant differences in patient characteristics between depressed and nondepressed patients, and binary logistic regression was used to assess the potential relationship between nocturia and depression while controlling for patient demographics and quality of life.
Of the cohort, 17.0% screened positive for depression. Depressed and nondepressed patients reported a mean (SD) of 2.7 (1.4) and 1.9 (1.4) episodes of nocturia per night, respectively (P <.001). After controlling for demographic variables and overall quality of life, patients with 5 or more episodes of nocturia per night experienced a 6.5-fold increased risk of depression compared with patients without nocturia (OR, 6.530; 95% CI, 2.107-20.239, P <.001).
A significant correlation exists between nocturia and depression. Consequently, clinicians might use nocturia as a predictor of depression. Patients with increased frequency of nocturia may be considered for referral for further mental health evaluation.
评估夜尿症和抑郁症之间的关系，这两种炎症状况影响着全球大量男性。
我们要求 547 名男性患者自行填写美国泌尿协会症状评分（AUA-SS）和老年抑郁量表（GDS），这是一种用于抑郁症筛查的有效工具。单因素分析确定了抑郁患者和非抑郁患者在患者特征方面的显著差异，二元逻辑回归用于评估在控制患者人口统计学和生活质量的情况下，夜尿症与抑郁症之间的潜在关系。
队列中，17.0%的患者筛查出抑郁症。抑郁和非抑郁患者报告的夜间夜尿症平均（SD）分别为 2.7（1.4）和 1.9（1.4）次（P <.001）。在控制人口统计学变量和整体生活质量后，每晚有 5 次或更多次夜尿症的患者患抑郁症的风险增加 6.5 倍，而非夜尿症患者的风险增加 6.5 倍（OR，6.530；95%CI，2.107-20.239，P <.001）。
夜尿症和抑郁症之间存在显著相关性。因此，临床医生可以将夜尿症作为预测抑郁症的指标。夜尿症频率增加的患者可能需要考虑转介进行进一步的心理健康评估。
