蛋白质生物制药的翻译后修饰。

Post-translational modifications of protein biopharmaceuticals.

机构信息

Department of Chemical and Environmental Sciences and the Materials and Surface Science Institute, University of Limerick, Limerick City, Ireland.

出版信息

Drug Discov Today. 2010 Sep;15(17-18):773-80. doi: 10.1016/j.drudis.2010.06.009. Epub 2010 Jun 25.

DOI:10.1016/j.drudis.2010.06.009

PMID:20599624

Abstract

The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make. This review considers the PTMs most often associated with therapeutic proteins and focuses upon more recent advances in engineering PTMs with the aim of improving the application-relevant functional characteristics of these drugs.

摘要

大多数治疗性蛋白都表现出一种或多种翻译后修饰（PTM）。这些修饰通常会影响这些蛋白的生化和治疗特性。选择一个能够产生适当产物 PTM 谱的表达系统仍然是药物开发者必须做出的最关键决策之一。本综述考虑了与治疗性蛋白最常相关的 PTM，并重点介绍了近年来在工程 PTM 方面的最新进展，旨在改善这些药物的应用相关功能特性。