中脑边缘多巴胺在调节滥用药物与社会行为相互作用中的作用。
The role of mesocorticolimbic dopamine in regulating interactions between drugs of abuse and social behavior.
机构信息
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.
出版信息
Neurosci Biobehav Rev. 2011 Jan;35(3):498-515. doi: 10.1016/j.neubiorev.2010.06.004. Epub 2010 Jun 23.
Abstract
The use of addictive drugs can have profound short- and long-term consequences on social behaviors. Similarly, social experiences and the presence or absence of social attachments during early development and throughout life can greatly influence drug intake and the susceptibility to drug abuse. The following review details this reciprocal interaction, focusing on common drugs of abuse (e.g., psychostimulants, opiates, alcohol and nicotine) and social behaviors (e.g., maternal, sexual, play, aggressive and bonding behaviors). The neural mechanisms underlying this interaction are discussed, with a particular emphasis on the involvement of the mesocorticolimbic dopamine system.
摘要
成瘾药物的使用会对社交行为产生深远的短期和长期影响。同样，早期发育和整个生命周期中的社会经验以及社会联系的存在或缺失也会极大地影响药物摄入和对药物滥用的易感性。以下综述详细说明了这种相互作用，重点介绍了常见的滥用药物（例如，精神兴奋剂、阿片类药物、酒精和尼古丁）和社交行为（例如，母婴、性、玩耍、攻击和结合行为）。讨论了这种相互作用的神经机制，特别强调了中脑边缘多巴胺系统的参与。
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