INRA, UMR1079 SENAH, Domaine de la Prise, Saint Gilles, France.
Appetite. 2010 Oct;55(2):245-52. doi: 10.1016/j.appet.2010.06.008. Epub 2010 Jun 19.
Chronic vagus nerve stimulation (VNS) is known to influence food intake and body weight in animals and humans. The aim of our work was to evaluate the effects of long-term VNS in adult obese minipigs. Eight minipigs were fed ad libitum a Western diet to cause obesity, after which half of the animals were implanted with bilateral vagal electrodes connected to constant current stimulators (2mA, 30Hz, 500-μs pulse, ON 30s, OFF 5min). The other animals were implanted with sham devices. Animals were weighed weekly and their daily consumption was measured. Still 14 weeks after surgery, VNS animals (70.3±3.3kg, P>0.10) did not significantly gain weight compared to sham animals (80.6±8.0kg, P<0.05). Furthermore, food consumption decreased in VNS animals (-18%, P<0.02) compared to sham animals (+1%, P>0.10). When subjected to a three-choice meal test (high-fat vs. high-carbohydrates vs. balanced diet), VNS animals decreased their sweet-food consumption compared to sham animals (P<0.05), and increased their balanced diet consumption in comparison to pre-surgery levels. Our results showed that chronic VNS decreased weight gain, food consumption and sweet craving in adult obese minipigs, which indicates that this therapy might be used to decrease appetite in the context of morbid obesity.
慢性迷走神经刺激（VNS）已知可影响动物和人类的食物摄入和体重。我们的工作目的是评估长期 VNS 在成年肥胖小型猪中的作用。8 头小型猪自由摄取西方饮食导致肥胖，然后将一半动物植入双侧迷走神经电极，连接到恒流刺激器（2mA、30Hz、500-μs 脉冲、ON 30s、OFF 5min）。其他动物植入假装置。每周测量动物体重，每天测量其食物摄入量。手术后仍 14 周，VNS 动物（70.3±3.3kg，P>0.10）与假装置动物（80.6±8.0kg，P<0.05）相比体重无显著增加。此外，与假装置动物（+1%，P>0.10）相比，VNS 动物的食物摄入量减少（-18%，P<0.02）。当进行三种选择的膳食测试（高脂肪与高碳水化合物与平衡饮食）时，与假装置动物相比，VNS 动物减少了对甜食的摄入（P<0.05），并且与术前水平相比增加了对平衡饮食的摄入。我们的结果表明，慢性 VNS 可减少成年肥胖小型猪的体重增加、食物摄入和甜食渴望，这表明这种治疗方法可用于减少病态肥胖患者的食欲。
