Department of Orthopedic, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Bone. 2010 Sep;47(3):681-6. doi: 10.1016/j.bone.2010.06.024. Epub 2010 Jun 28.
Vitamin D receptor (VDR) gene polymorphisms have been strongly associated with bone mineral density in some studies. However, in a recent meta-analysis, no relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.
Our meta-analysis studied whether a relationship exists between BsmI, TaqI, ApaI and FokI polymorphisms in the VDR gene and risk of fracture.
Relevant studies were identified from the following electronic databases: MEDLINE, EMBASE and Current Contents before January 2010.
This meta-analysis included 17 studies with a total of 21 eligible comparisons, which included 2112 fracture cases and 4521 controls. All of these studies reported on Caucasians. The combined results based on all studies showed that fracture cases had a significantly lower frequency of bb genotype of BsmI [odds ratio (OR) = 0.87, 95% confidence interval (CI)=0.76, 0.98]. When stratifying by fracture type, we found that (1) hip fracture cases had a significantly lower frequency of bb genotype of BsmI (OR=0.82, 95% CI=0.70, 0.97); (2) hip fracture cases had a significantly lower frequency of Tt genotype of TaqI (OR=0.65, 95% CI=0.43, 0.97); (3) hip fracture cases had a significantly higher frequency of tt genotype of TaqI (OR=1.74, 95% CI=1.05, 2.91); (4) vertebral fracture cases had a significantly higher frequency of Aa genotype of ApaI (OR=1.63, 95% CI=1.03, 2.59). No significant difference was found in any genotype of FokI.
Our meta-analysis suggests that there is a modest but statistically significant association between the BsmI bb genotypes and fracture.
维生素 D 受体 (VDR) 基因多态性与一些研究中的骨密度密切相关。然而，在最近的一项荟萃分析中，对已发表数据的荟萃分析并未发现 VDR BsmI 或 TaqI 多态性与骨折风险之间存在关系。
我们的荟萃分析研究了 VDR 基因中的 BsmI、TaqI、ApaI 和 FokI 多态性与骨折风险之间是否存在关系。
从以下电子数据库中确定了相关研究：MEDLINE、EMBASE 和 2010 年 1 月前的 Current Contents。
本荟萃分析纳入了 17 项研究，共 21 项符合条件的比较，包括 2112 例骨折病例和 4521 例对照。所有这些研究都报告了高加索人。基于所有研究的综合结果表明，骨折病例的 BsmI bb 基因型频率显著降低[比值比 (OR)=0.87，95%置信区间 (CI)=0.76, 0.98]。按骨折类型分层时，我们发现：(1)髋部骨折病例的 BsmI bb 基因型频率显著降低(OR=0.82，95% CI=0.70, 0.97)；(2)髋部骨折病例的 TaqI Tt 基因型频率显著降低(OR=0.65，95% CI=0.43, 0.97)；(3)髋部骨折病例的 TaqI tt 基因型频率显著升高(OR=1.74，95% CI=1.05, 2.91)；(4)椎体骨折病例的 ApaI Aa 基因型频率显著升高(OR=1.63，95% CI=1.03, 2.59)。FokI 的任何基因型均无显著差异。
我们的荟萃分析表明，BsmI bb 基因型与骨折之间存在适度但具有统计学意义的关联。
