Department of Urology, University of California, 400 Parnassus St, Ste A-633, Campus Box 0738, San Francisco, CA 94143, USA.
Hum Reprod. 2010 Sep;25(9):2360-5. doi: 10.1093/humrep/deq152. Epub 2010 Jul 3.
Investigators have postulated that family size may be influenced by biologic fertility potential in addition to sociodemographic factors. The aim of the current study is to determine if a diagnosis of infertility is associated with family size in the USA.
We analyzed data from the male and female samples of the 2002 National Survey of Family Growth using multivariable logistic regression models to determine the relationship between infertility and family size while adjusting for sociodemographic and reproductive characteristics.
In the survey, 4409 women and 1739 men met the inclusion criteria, of whom 10.2% and 9.7%, respectively, were classified as infertile, on the basis of having sought reproductive assistance. Infertile females had a 34% reduced odds of having an additional child compared with women who did not seek reproductive assistance. For each additional 6 months it took a woman to conceive her first child, the odds of having a larger family fell by 9% and the odds of having a second child were reduced by 11%. A diagnosis of male infertility reduced the odds of having a larger family more than a diagnosis of female infertility.
A diagnosis of infertility, especially male factor, is associated with reduced odds of having a larger family, implicating a biologic role in the determination of family size in the USA.
研究人员推测，家庭规模除了社会人口因素外，还可能受到生物生育能力的影响。本研究的目的是确定在美国，不孕诊断是否与家庭规模有关。
我们分析了 2002 年全国家庭增长调查的男性和女性样本数据，使用多变量逻辑回归模型来确定不孕与家庭规模之间的关系，同时调整了社会人口和生殖特征。
在调查中，4409 名女性和 1739 名男性符合纳入标准，其中分别有 10.2%和 9.7%的人因寻求生殖援助而被归类为不孕。与未寻求生殖援助的女性相比，不孕女性生育额外子女的几率降低了 34%。女性首次怀孕所需的时间每增加 6 个月，生育更大家庭的几率就会降低 9%，生育第二胎的几率就会降低 11%。男性不孕的诊断比女性不孕的诊断更能降低生育更大家庭的几率。
不孕的诊断，特别是男性因素，与生育更大家庭的几率降低有关，这意味着在美国，生物因素在决定家庭规模方面起着作用。
