HIV/STI Intervention and Prevention Studies, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota 55454, USA.
AIDS. 2010 Aug 24;24(13):2099-107. doi: 10.1097/QAD.0b013e32833c4ac7.
The primary objective of this study was to develop and test a highly interactive Internet-based HIV prevention intervention for men who have sex with men (MSM). MSM remain the group at highest risk for HIV/AIDS in the United States and similar countries. As the Internet becomes popular for seeking sex, online interventions to reduce sexual risk are critical. Given previous studies, a secondary objective was to demonstrate that good retention is possible in online trials.
A randomized controlled trial with 3-month, 6-month, 9-month, and 12-month follow-up design was employed.
In 2008, 650 participants were randomized to an online, interactive sexual risk reduction intervention or to a waitlist null control.
Retention was 76-89% over 12 months. At 3-month follow-up, results showed a 16% reduction in reported unprotected anal intercourse risk among those in the treatment condition versus control [95% confidence interval (95% CI) of rate ratio: 0.70-1.01]. No meaningful differences were observed at 12-month follow-up.
Internet-based, persuasive computing programs hold promise as an effective new approach to HIV prevention for MSM, at least in the short term. Further, online trials can be conducted with acceptable retention provided strong retention protocols are employed. Four directions for future research are identified.
本研究的主要目的是为男男性行为者（MSM）开发和测试一种高度互动的基于互联网的艾滋病预防干预措施。MSM 仍然是美国和类似国家中 HIV/AIDS 风险最高的群体。随着互联网在寻求性方面的普及，减少性风险的在线干预措施至关重要。鉴于先前的研究，次要目标是证明在线试验中可以实现良好的保留率。
采用随机对照试验设计，具有 3 个月、6 个月、9 个月和 12 个月的随访设计。
2008 年，650 名参与者被随机分配到在线互动性风险降低干预组或等待名单对照组。
12 个月内的保留率为 76-89%。在 3 个月的随访中，与对照组相比，治疗组报告的无保护肛交风险降低了 16%[95%置信区间（95%CI）的比率比：0.70-1.01]。在 12 个月的随访中没有观察到有意义的差异。
基于互联网的说服性计算程序有望成为 MSM 艾滋病预防的一种有效新方法，至少在短期内如此。此外，只要采用强有力的保留协议，就可以进行在线试验，并且可以实现可接受的保留率。确定了四个未来研究方向。
