Bull World Health Organ. 1970;42(5):673-702.
A critical survey of the literature on serology in leprosy has shown that sera taken from lepromatous patients display some striking differences in comparison with sera from tuberculoid patients. The tests most frequently employed were complement-fixation, haemagglutination, electrophoresis, precipitation and immunofluorescence, together with a variety of antigens not only from lepromas but also from Mycobacterium tuberculosis and other actinomycetales.With the exception of the Rubino test, all these serological tests are lacking in specificity for leprosy since leprous sera have a broad range of reactivity with different antigens, including those employed in the serological diagnosis of syphilis.Some features of the leprous sera could be related to a hypersensitivity state involving circulating immune complexes, low levels of complement and the presence of antibodies similar to those found in sera from patients with autoimmune diseases.
对麻风病血清学文献的批判性调查表明，麻风患者的血清与结核样患者的血清相比存在一些显著差异。最常使用的检测方法包括补体固定、血凝、电泳、沉淀和免疫荧光，以及各种不仅来自麻风结节，还来自结核分枝杆菌和其他放线菌的抗原。除了鲁比诺试验外，所有这些血清学试验对麻风病都缺乏特异性，因为麻风病血清与不同抗原具有广泛的反应性，包括用于梅毒血清学诊断的抗原。麻风病血清的一些特征可能与涉及循环免疫复合物、补体水平低和存在类似于自身免疫性疾病患者血清中抗体的过敏状态有关。
