Xie Wei-Dong, Niu Yu-Fang, Lai Peng-Xiang, Row Kyung-Ho
Marine College, Shandong University at Weihai, Weihai, P. R. China.
Chem Pharm Bull (Tokyo). 2010 Jul;58(7):991-4. doi: 10.1248/cpb.58.991.
Three new sesquiterpenoids, isodauc-7(14)-en-6alpha,10beta-diol (1), 10beta-hydroxyisodauc-6-en-14-al (2), and (7S(*))-opposit-4(15)-en-1beta,7-diol (4), along with ten known compounds have been isolated from the aerial parts of Senecio argunensis. Their structures were established by means of detailed spectroscopic analysis including IR, HR-MS, and 1D NMR and 2D NMR data. The sesquiterpenoids were assayed against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Compounds 4 exhibited weak antibacterial activity against Escherichia coli and Bacillus subtilis.
从东北千里光的地上部分分离出了三种新的倍半萜类化合物，异胡萝卜-7(14)-烯-6α,10β-二醇（1）、10β-羟基异胡萝卜-6-烯-14-醛（2）和(7S(*))-对映-4(15)-烯-1β,7-二醇（4），以及十种已知化合物。通过包括红外光谱、高分辨质谱、一维核磁共振和二维核磁共振数据在内的详细光谱分析确定了它们的结构。对这些倍半萜类化合物针对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌进行了测定。化合物4对大肠杆菌和枯草芽孢杆菌表现出微弱的抗菌活性。
