Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of .

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (), and germacrane, 9β-hydroxyparthenolide-9--β-D-glucopyranoside (), classes have been isolated from the leaves of the Saudi medicinal plant along with seven known compounds (-). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of - were screened against seven different pathogenic microbes, and compounds - showed a potent antifungal activity.