Institut National de Santé Publique, Algiers, Algeria.
Int J Cancer. 2011 May 1;128(9):2224-9. doi: 10.1002/ijc.25539.
No data exist on the population prevalence of, nor risk factors for, human papillomavirus (HPV) infection in the predominantly Muslim countries of Northern Africa. Cervical specimens were obtained from 759 married women aged 15-65 years from the general population of Algiers, Algeria. Liquid-based cytology and HPV DNA detection, using a GP5+/6+-based polymerase chain reaction assay that detects 44 HPV types, were performed according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV prevalence in the general population was 6.3% (4.0% of high-risk types), with no significant variation by age. The prevalence of cervical abnormalities was 3.6%. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's extramarital sexual relationships. HPV16/18 accounted for only 15% of HPV-positive women in the general population, compared with 77% of invasive cervical cancer diagnosed in the same city. In conclusion, we report that HPV infection among married women in Algeria is much lower than in sub-Saharan Africa and also lower than in the majority of high-resource countries.
在以穆斯林为主的北非国家，关于人乳头瘤病毒（HPV）感染的流行率和危险因素，目前尚无数据。本研究从阿尔及利亚首都阿尔及尔的一般人群中招募了 759 名年龄在 15-65 岁之间的已婚女性，采集了她们的宫颈标本。采用液基细胞学检查和 HPV DNA 检测，应用基于 GP5+/6+的聚合酶链反应（PCR）检测 44 种 HPV 型别。检测方法遵循国际癌症研究机构 HPV 流行率调查的标准化方案。一般人群 HPV 流行率为 6.3%（高危型别占 4.0%），不同年龄组间无明显差异。宫颈异常的患病率为 3.6%。离异、多配偶婚姻和报告丈夫婚外性行为的女性 HPV 阳性率显著更高。HPV16/18 型在一般人群 HPV 阳性女性中的比例仅为 15%，而在同一城市诊断的浸润性宫颈癌中占 77%。综上所述，我们报告称，阿尔及利亚已婚女性的 HPV 感染率明显低于撒哈拉以南非洲，也低于大多数高资源国家。
