生殖中心的细胞舞蹈：活体成像的新视角。
Cellular choreography in the germinal center: new visions from in vivo imaging.
机构信息
Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin 10117, Germany.
出版信息
Semin Immunopathol. 2010 Sep;32(3):239-55. doi: 10.1007/s00281-010-0214-z. Epub 2010 Jul 9.
Abstract
Germinal centers (GC) are large aggregates of proliferating B lymphocytes within follicles of lymphoid tissue that form during adaptive immune responses. GCs are the source of long-lived B cells that form the basis for pathogen-specific lifelong B cell immunity. The complex architecture of these structures includes subdomains that differ significantly in their stromal cell and T lymphocyte subset composition. In part due to their structural complexity and potential to generate some lymphomas, much interest and many theories about GC dynamics have emerged. Here, we review recent research employing in vivo imaging that has begun to untangle some of the mysteries.
摘要
生发中心（GC）是在适应性免疫反应过程中形成于淋巴组织滤泡内的大量增殖 B 淋巴细胞聚集物。GC 是产生长寿命 B 细胞的源泉，这些细胞是病原体特异性终身 B 细胞免疫的基础。这些结构的复杂结构包括在基质细胞和 T 淋巴细胞亚群组成方面有显著差异的子域。部分由于其结构复杂性和产生某些淋巴瘤的潜力，人们对 GC 动力学产生了浓厚的兴趣并提出了许多理论。在这里，我们回顾了最近使用体内成像技术的研究，这些研究开始解开一些谜团。
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