Rogers P, Murphy C, Cameron I, Leeton J, Hosie M, Beaton L, Macpherson A
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Melbourne, Victoria, Australia.
Hum Reprod. 1989 May;4(4):349-54. doi: 10.1093/oxfordjournals.humrep.a136906.
Endometrial biopsies and plasma oestradiol (E2) and progesterone (P4) levels in 23 patients were evaluated during 26 replacement therapy cycles for premature ovarian failure. Plasma E2 and P4 levels showed wide patient to patient variability, despite each patient being given the same hormone replacement therapy. Biopsies were studied by conventional histological dating and scanning electron microscopy (SEM). Eight morphological features of the surface epithelium that have previously been linked to uterine receptivity for implantation were identified and quantified. No correlation was found between endometrial surface morphology by SEM and circulating E2 and P4 levels. The results of this study do not support the hypothesis that there is an obligatory link between any of the eight morphological features measured in this study and uterine receptivity for implantation. To date, three ongoing pregnancies have been achieved following 18 embryo transfers to a total of 10 of the women in the study group.
对23例患者在26个卵巢早衰替代治疗周期中进行了子宫内膜活检，并检测了血浆雌二醇（E2）和孕酮（P4）水平。尽管每位患者接受的激素替代治疗相同，但血浆E2和P4水平在患者之间仍显示出很大差异。活检采用传统组织学分期和扫描电子显微镜（SEM）进行研究。确定并量化了先前与子宫着床接受性相关的表面上皮的八个形态学特征。通过SEM观察的子宫内膜表面形态与循环E2和P4水平之间未发现相关性。本研究结果不支持以下假设：本研究中测量的八个形态学特征中的任何一个与子宫着床接受性之间存在必然联系。迄今为止，研究组中共有10名女性接受了18次胚胎移植，已有3例成功妊娠。
