Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA.
BMC Biol. 2010 Jul 1;8:84. doi: 10.1186/1741-7007-8-84.
Blood is the pipeline of the immune system. Assessing changes in transcript abundance in blood on a genome-wide scale affords a comprehensive view of the status of the immune system in health and disease. This review summarizes the work that has used this approach to identify therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed.
血液是免疫系统的管道。在全基因组范围内评估血液中转录物丰度的变化，可以全面了解免疫系统在健康和疾病中的状态。本文综述了利用这种方法在自身免疫和传染病领域识别治疗靶点和生物标志物特征的研究工作。还讨论了将推动血液转录组研究领域前进的最新技术和方法学进展。
