Erukainure Ochuko L, Abovwe Joseph A, Adefegha Adeniyi S, Egwuche Rabiat U, Fafunso Michael A
Food Technology Division, Federal Institute of Industrial Research, P.M.B. 21023, Ikeja, Lagos, Nigeria.
Exp Toxicol Pathol. 2011 Nov;63(7-8):657-61. doi: 10.1016/j.etp.2010.05.007. Epub 2010 Jul 9.
Antilipemic/hypocholestermic activities of the methanolic extracts of Globimetula braunii were studied in the tissues of normo and hypercholesteremic rats. Hypercholesteremia was induced in the rats by feeding with dietary cholesterol at a dose of 40 mg/kg body weight. A significant increase (p<0.05) was observed in the body and the visceral organs relative weights in all the groups. There was a significant decrease in HDL-cholesterol and a significant increase in the levels of LDL, total cholesterol and triglycerides in hypercholesteremic rats when compared to normo rats. Administration of the methanolic extracts restored the elevated levels of serum lipids to normal. The methanolic extracts of G. braunii produced a significant (p<0.05) decrease in the levels of total cholesterol, triglyceride, LDL-cholesterol and lipid peroxidation of the extract treated group compared to hypercholesteremic control. There was a significant (p<0.05) increase in the levels of HDL-cholesterol as compared to hypercholesteremic control. The results obtained from this study are indications of the antilipemic and hypocholestermic activities of G. braunii as well as its cardio-protective potential in normo and hypercholesteremia conditions.
在正常和高胆固醇血症大鼠组织中研究了布氏球果樟甲醇提取物的抗血脂/降胆固醇活性。通过以40mg/kg体重的剂量喂食膳食胆固醇诱导大鼠高胆固醇血症。在所有组中，观察到身体和内脏器官相对重量显著增加（p<0.05）。与正常大鼠相比，高胆固醇血症大鼠的高密度脂蛋白胆固醇显著降低，低密度脂蛋白、总胆固醇和甘油三酯水平显著升高。给予甲醇提取物可使血清脂质升高水平恢复正常。与高胆固醇血症对照组相比，布氏球果樟甲醇提取物使提取物处理组的总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平和脂质过氧化显著降低（p<0.05）。与高胆固醇血症对照组相比，高密度脂蛋白胆固醇水平显著升高（p<0.05）。本研究获得的结果表明布氏球果樟在正常和高胆固醇血症条件下具有抗血脂和降胆固醇活性以及心脏保护潜力。
