Nakahara Kazushige, Michikawa Takehiro, Morokuma Seiichi, Hamada Norio, Ogawa Masanobu, Kato Kiyoko, Sanefuji Masafumi, Shibata Eiji, Tsuji Mayumi, Shimono Masayuki, Kawamoto Toshihiro, Ohga Shouichi, Kusuhara Koichi
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.
Department of Environmental and Occupational Health, School of Medicine Toho University Tokyo Japan.
Health Sci Rep. 2022 Mar 9;5(2):e552. doi: 10.1002/hsr2.552. eCollection 2022 Mar.
Maternal hemoglobin concentration during pregnancy is reported to be associated with various perinatal outcomes and may also be associated with infant development. This study aims to investigate the association between maternal hemoglobin levels during early or mid-pregnancy and sleep and developmental problems in 1-year-old infants.
We used the data of 66,935 pregnant women who were participants of the Japan Environment and Children's Study, a nationwide cohort study in Japan, between 2011 and 2014. Maternal hemoglobin level was examined at recruitment (mean gestational age, 15.3 weeks; SD, 2.85 weeks; range, 6-22 weeks). Information on infant sleep and development at the age of 1 year was acquired using a questionnaire. Infant development was evaluated using the Ages and Stages Questionnaire (ASQ).
The mean (SD) maternal hemoglobin level was 12.0 (1.0) g/dl. Maternal hemoglobin levels were not associated with the majority of infant sleep and developmental outcomes. In the group with maternal hemoglobin <10.0 g/dl, the risk ratio (RR) for sleep at 22:00 or later was higher than that in the reference group with 11.0 g/dl ≤ hemoglobin < 14.0 g/dl (RR 1.12, 95% confidence interval = 1.00-1.25). In the analysis with maternal hemoglobin level as a continuous variable, both high and low hemoglobin levels were associated with a higher RR of a late bedtime. In addition, a low maternal hemoglobin level was associated with a higher RR for abnormal fine motor skills in the ASQ.
Our results suggest that a low level of maternal hemoglobin during pregnancy is associated with late bedtime and abnormal fine motor skills in 1-year-old infants. Conversely, a high level of maternal hemoglobin may also be associated with the infant's late bedtime.
据报道，孕期母体血红蛋白浓度与各种围产期结局相关，也可能与婴儿发育有关。本研究旨在调查孕早期或孕中期母体血红蛋白水平与1岁婴儿睡眠及发育问题之间的关联。
我们使用了2011年至2014年间参与日本环境与儿童研究（一项日本全国性队列研究）的66935名孕妇的数据。在招募时检测母体血红蛋白水平（平均孕周15.3周；标准差2.85周；范围6 - 22周）。通过问卷调查获取1岁婴儿睡眠和发育的信息。使用年龄与发育进程问卷（ASQ）评估婴儿发育情况。
母体血红蛋白水平的均值（标准差）为12.0（1.0）g/dl。母体血红蛋白水平与大多数婴儿睡眠及发育结局无关。在母体血红蛋白<10.0 g/dl的组中，22:00及以后入睡的风险比（RR）高于血红蛋白水平在11.0 g/dl≤血红蛋白<14.0 g/dl的参照组（RR 1.12，95%置信区间 = 1.00 - 1.25）。在将母体血红蛋白水平作为连续变量的分析中，高血红蛋白水平和低血红蛋白水平均与较晚就寝时间的较高RR相关。此外，母体血红蛋白水平低与ASQ中精细运动技能异常的较高RR相关。
我们的结果表明，孕期母体血红蛋白水平低与1岁婴儿就寝时间晚及精细运动技能异常有关。相反，母体血红蛋白水平高也可能与婴儿就寝时间晚有关。
