Gittelman P D, Jacobs J B, Lebowitz A S, Tierno P M
Department of Otolaryngology, New York University Medical Center, NY 10016.
Laryngoscope. 1991 Jul;101(7 Pt 1):733-7. doi: 10.1288/00005537-199107000-00007.
Toxic shock syndrome has been associated with rhinologic surgery and medical devices, and it has been linked to a circulating exotoxin of a toxogenic strain of Staphylococcus aureus. One hundred forty patients with rhinosinusitis were studied. Nasal cultures were obtained. The microbiological characteristics are described. The carrier rate for Staphylococcus aureus was 35%. Thirty percent of patients selected for surgery were Staphylococcus aureus carriers. Toxin-capable isolates were identified in 40% of those tested. Users of cocaine, topical decongestants, and steroid sprays had a statistically higher rate of Staphylococcus aureus carriage compared to nonusers. It is hoped that by identifying the population at risk and defining the factors associated with the development of toxic shock syndrome, a cogent policy of prevention can be established.
中毒性休克综合征与鼻科手术及医疗器械有关，且与金黄色葡萄球菌产毒株的循环外毒素有关。对140例鼻窦炎患者进行了研究。采集了鼻拭子培养物。描述了微生物学特征。金黄色葡萄球菌的携带率为35%。被选做手术的患者中有30%是金黄色葡萄球菌携带者。在40%的检测对象中鉴定出了产毒素菌株。与未使用者相比，可卡因、局部减充血剂和类固醇喷雾剂使用者的金黄色葡萄球菌携带率在统计学上更高。希望通过识别高危人群并确定与中毒性休克综合征发生相关的因素，能够制定出有说服力的预防政策。
