Materials Science and Engineering, School of Engineering Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA.
Nanotechnology. 2010 Aug 6;21(31):315102. doi: 10.1088/0957-4484/21/31/315102. Epub 2010 Jul 12.
Carbon-nanotube-based substrates have been shown to support the growth of different cell types and, as such, have raised considerable interest in view of their possible use in biomedical applications. Nanotube matrices are embedded in polymers which cause inherent changes in nanotube chemical and physical film properties. Thus, it is critical to understand how the physical properties of the film affect the biology of the host tissue. Here, we investigated how the physical and chemical properties of single-walled carbon nanotubes (SWNT) films impact the response of MC3T3-E1 bone osteoblasts. We found that two fundamental steps in cell growth-initial attachment to the substrate and proliferation-are strongly dependent on, respectively, the energy and roughness of the surface. Thus, fine-tuning the properties of the film may represent a valid strategy to optimize the response of the biological host.
基于碳纳米管的基底已被证明能够支持不同细胞类型的生长，因此，鉴于它们在生物医学应用中的潜在用途，引起了相当大的兴趣。纳米管基质嵌入在聚合物中，这会导致纳米管化学和物理薄膜性质的固有变化。因此，了解薄膜的物理性质如何影响宿主组织的生物学特性至关重要。在这里，我们研究了单壁碳纳米管（SWNT）薄膜的物理和化学性质如何影响 MC3T3-E1 成骨细胞的反应。我们发现，细胞生长的两个基本步骤——初始附着到基质和增殖——分别强烈依赖于表面的能量和粗糙度。因此，精细调整薄膜的特性可能是优化生物宿主反应的有效策略。
