Sandhu G S, Steele R, Gonnella N C
Research Department Pharma Division, CIBA-GEIGY Corporation, Summit, New Jersey 07901.
Magn Reson Med. 1991 Mar;18(1):237-43. doi: 10.1002/mrm.1910180125.
31P NMR spectroscopy was used to monitor the cardiac energy metabolism in hypothyroid rat hearts. Differential alterations in phosphocreatine and inorganic phosphate levels were observed upon treatment of hypothyroid animals with DT4 and LT4, while both agents were equipotent in reducing cholesterol. These results show potential for NMR spectroscopy as a technique to determine therapeutic selectivity.
采用31P核磁共振波谱法监测甲状腺功能减退大鼠心脏的能量代谢。在用DT4和LT4治疗甲状腺功能减退动物后，观察到磷酸肌酸和无机磷酸盐水平的差异变化，而两种药物在降低胆固醇方面具有同等效力。这些结果表明核磁共振波谱法作为一种确定治疗选择性的技术具有潜力。
