Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Future Oncol. 2010 Jul;6(7):1117-26. doi: 10.2217/fon.10.67.
Aptamers are single-stranded DNA or RNA oligonucleotides that assume specific 3D structures and bind to target molecules with high affinity. The unique specificity of aptamers has made them attractive agents for targeted cancer therapy. Aptamers have been developed against a variety of cancer targets, including extracellular ligands and cell surface proteins. In addition, aptamers have been incorporated into novel constructs involving siRNAs, chemotherapeutic agents, cell toxins and nanoparticles, in which they function as delivery agents for therapeutic cargo. In this article, we review recent developments in the use of aptamers for targeted cancer therapy, particularly focusing on novel applications of aptamers targeting the cell surface.
适配体是单链 DNA 或 RNA 寡核苷酸，它们具有特定的 3D 结构，并与靶分子高亲和力结合。适配体的独特特异性使其成为靶向癌症治疗的有吸引力的药物。已经针对各种癌症靶点开发了适配体，包括细胞外配体和细胞表面蛋白。此外，适配体已被纳入涉及 siRNA、化疗药物、细胞毒素和纳米粒子的新型构建体中，在这些构建体中，它们作为治疗货物的递药载体发挥作用。在本文中，我们综述了适配体在靶向癌症治疗中的最新进展，特别关注针对细胞表面的适配体的新应用。
