Liu Qiaoling, Jin Chen, Wang Yanyue, Fang Xiaohong, Zhang Xiaobing, Chen Zhuo, Tan Weihong
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China.
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P.R. China.
NPG Asia Mater. 2014;6. doi: 10.1038/am.2014.12. Epub 2014 Apr 11.
Based on their unique advantages, increasing interest has been shown in the use of aptamers as target ligands for specific cancer cell recognition and targeted cancer therapy. Recently, the development of aptamer-conjugated nanomaterials has offered new therapeutic opportunities for cancer treatment with better efficacy and lower toxicity. We highlight some of the promising classes of aptamer-conjugated nanomaterials for the specific recognition of cancer cells and targeted cancer therapy. Recent developments in the use of novel strategies that enable sensitive and selective cancer cell recognition are introduced. In addition to targeted drug delivery for chemotherapy, we also review how aptamer-conjugated nanomaterials are being incorporated into emerging technologies with significant improvement in efficiency and selectivity in cancer treatment.
基于其独特优势，适体作为特异性癌细胞识别和靶向癌症治疗的靶标配体，已引发越来越多的关注。最近，适体缀合纳米材料的发展为癌症治疗提供了新的治疗机会，疗效更好且毒性更低。我们重点介绍了一些有望用于特异性识别癌细胞和靶向癌症治疗的适体缀合纳米材料类别。介绍了使用能够实现灵敏且选择性癌细胞识别的新策略的最新进展。除了用于化疗的靶向药物递送外，我们还综述了适体缀合纳米材料如何被纳入新兴技术，从而在癌症治疗中显著提高效率和选择性。
