Key Laboratory of Parasitology and Vector Biology, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China.
Adv Parasitol. 2010;73:327-71. doi: 10.1016/S0065-308X(10)73011-6.
Helminths are the cause of some of the major infectious diseases of humanity in what is still a "wormy" world. There is, in East and Southeast Asia, a high prevalence of several helminthiases which occur primarily in rural, impoverished areas of low-income and developing countries throughout the tropics and subtropics. Subsequent to various parasite genome projects that commenced in the early 1990s, under the aegis of the World Health Organization (WHO), the draft genomes of three major helminth species (Schistosoma japonicum, S. mansoni and Brugia malayi) have been sequenced, and many other helminth parasites have now been targeted for intensive genomics investigation. The continuing release of genome sequences has catalyzed the emergence of transcriptomics, proteomics and related "-omics" analyses of helminth parasites, which provide unprecedented approaches to understanding their biology that will result in new clues for the development of novel control interventions. In this review, we present a summary of current approaches employed in helminth "-omics" studies and review recent advances in helminth genomics and post-genomics in the Southeast Asian setting.
在这个仍然“多虫”的世界里，蠕虫是导致一些人类主要传染病的原因。在东亚和东南亚，几种蠕虫病的发病率很高，这些蠕虫病主要发生在热带和亚热带低收入和发展中国家的农村贫困地区。自 20 世纪 90 年代初世界卫生组织（WHO）发起各种寄生虫基因组项目以来，三种主要蠕虫（日本血吸虫、曼氏血吸虫和马来丝虫）的基因组草案已被测序，现在许多其他蠕虫寄生虫已成为密集基因组学研究的目标。基因组序列的不断发布促进了转录组学、蛋白质组学和相关“组学”分析的出现，为理解它们的生物学提供了前所未有的方法，这将为开发新的控制干预措施提供新的线索。在这篇综述中，我们总结了当前在蠕虫“组学”研究中使用的方法，并回顾了东南亚地区蠕虫基因组学和后基因组学的最新进展。
