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A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity.

作者信息

Tsitovich Pavel B, Pushechnikov Alexei, French Jonathan M, Disney Matthew D

机构信息

Department of Chemistry & The Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, 657 Natural Sciences Complex, Buffalo, NY 14260, USA.

出版信息

Chembiochem. 2010 Aug 16;11(12):1656-60. doi: 10.1002/cbic.201000300.

DOI:10.1002/cbic.201000300
PMID:20629012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3016878/
Abstract
摘要

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本文引用的文献

1
Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides.探索药物修饰酶的底物混杂性，用于化学酶法生成 N-酰化氨基糖苷。
Chembiochem. 2010 Jan 4;11(1):119-26. doi: 10.1002/cbic.200900584.
2
Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells.调节哺乳动物细胞中乙酰转移酶和去乙酰化酶活性的生化途径。
Trends Biochem Sci. 2009 Nov;34(11):571-8. doi: 10.1016/j.tibs.2009.06.010. Epub 2009 Oct 12.
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Sialic acids as regulators of molecular and cellular interactions.唾液酸作为分子与细胞相互作用的调节因子。
Curr Opin Struct Biol. 2009 Oct;19(5):507-14. doi: 10.1016/j.sbi.2009.06.003. Epub 2009 Aug 19.
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Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray.通过微阵列研究乙酰转移酶类耐药酶引起的氨基糖苷修饰。
Carbohydr Res. 2008 Nov 24;343(17):2924-31. doi: 10.1016/j.carres.2008.08.018. Epub 2008 Aug 22.
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Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners.二维组合筛选确定了特定的氨基糖苷-RNA内部环配对物。
J Am Chem Soc. 2008 Aug 20;130(33):11185-94. doi: 10.1021/ja803234t. Epub 2008 Jul 25.
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A small molecule microarray platform to select RNA internal loop-ligand interactions.一种用于筛选RNA内部环-配体相互作用的小分子微阵列平台。
ACS Chem Biol. 2007 Nov 20;2(11):745-54. doi: 10.1021/cb700174r. Epub 2007 Nov 2.
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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.氨基糖苷类药物抑制细菌核糖体循环的结构基础。
Nat Struct Mol Biol. 2007 Aug;14(8):727-32. doi: 10.1038/nsmb1271. Epub 2007 Jul 29.
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Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A.利用筛选来鉴定并通过化学微阵列研究6'-N-酰化卡那霉素A识别的RNA内部环。
Chembiochem. 2007 Apr 16;8(6):649-56. doi: 10.1002/cbic.200600569.
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Translational readthrough induction of pathogenic nonsense mutations.致病性无义突变的翻译通读诱导
Eur J Med Genet. 2006 Nov-Dec;49(6):445-50. doi: 10.1016/j.ejmg.2006.04.003. Epub 2006 May 19.
10
The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli.来自大肠杆菌的AAC3-IV氨基糖苷乙酰转移酶的动力学机制。
Biochemistry. 2005 Dec 13;44(49):16275-83. doi: 10.1021/bi051777d.