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A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity.

作者信息

Tsitovich Pavel B, Pushechnikov Alexei, French Jonathan M, Disney Matthew D

机构信息

Department of Chemistry & The Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, 657 Natural Sciences Complex, Buffalo, NY 14260, USA.

出版信息

Chembiochem. 2010 Aug 16;11(12):1656-60. doi: 10.1002/cbic.201000300.

Abstract
摘要

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本文引用的文献

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Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells.
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Sialic acids as regulators of molecular and cellular interactions.
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Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray.
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Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners.
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A small molecule microarray platform to select RNA internal loop-ligand interactions.
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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.
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Translational readthrough induction of pathogenic nonsense mutations.
Eur J Med Genet. 2006 Nov-Dec;49(6):445-50. doi: 10.1016/j.ejmg.2006.04.003. Epub 2006 May 19.
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The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli.
Biochemistry. 2005 Dec 13;44(49):16275-83. doi: 10.1021/bi051777d.

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