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厌恶脑刺激之间的辨别:刺激参数的影响

Discrimination between aversive brain stimulations: effect of stimulation parameters.

作者信息

Lappuke R, Schmitt P, Karli P

出版信息

Behav Neural Biol. 1984 Jul;41(2):164-79. doi: 10.1016/s0163-1047(84)90541-7.

DOI:10.1016/s0163-1047(84)90541-7
PMID:6487217
Abstract

Rats placed in a T maze were shown to be able to discriminate between two stimulations applied to one and the same brain site and inducing aversive effects of different magnitude. Discrimination occurred irrespective of whether the two stimulations differed in either intensity or frequency, and irrespective of whether they were applied to a medial hypothalamic or to a mesencephalic central gray site. Generalization experiments were performed in which either the stimulation parameter used to establish the discrimination or another parameter was varied. The results show that the animal's choice cannot be predicted on the sole basis of either the electrical charge/second applied or the escape latency induced.

摘要

实验表明,置于T型迷宫中的大鼠能够区分施加于同一脑区的两种刺激,这两种刺激会产生不同程度的厌恶效应。无论这两种刺激在强度或频率上是否不同,也无论它们是施加于下丘脑内侧还是中脑中央灰质区域,大鼠都能做出区分。实验还进行了泛化实验,在实验中改变用于建立区分的刺激参数或另一个参数。结果表明,仅根据每秒施加的电荷量或诱导的逃避潜伏期,无法预测动物的选择。

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