Ain Shams University, Department of Pharmaceutics, Faculty of Pharmacy, Monazamet El Wehda El Afrikia St, El Abbassia, Cairo, Egypt.
Expert Opin Drug Deliv. 2010 Aug;7(8):895-913. doi: 10.1517/17425247.2010.501792.
The last 10 years have seen a dramatic growth in understanding and controlling how complex, drug-loaded (nano)structures, as well as pathogens, or biopharmaceuticals can gather access to the cytoplasm, which is a key step to increasing the effectiveness of their action.
The review offers an updated overview of the current knowledge of endocytic processes; furthermore, the cell surface receptors most commonly used in drug delivery are here discussed on the basis of their reported internalization mechanisms, with examples of their use as nanocarrier targets taken from the most recent scientific literature.
Knowledge of molecular biology details is increasingly necessary for a rational design of drug delivery systems. Here, the aim is to provide the reader with an attempt to link a mechanistic knowledge of endocytic mechanisms with the identification of appropriate targets (internalization receptors) for nanocarriers.
Much advance is still needed to create a complete and coherent biological picture of endocytosis, but current knowledge already allows individuation of a good number of targetable groups for a predetermined intracellular fate of nanocarriers.
在过去的 10 年中，人们对复杂的载药（纳米）结构以及病原体或生物制药如何能够进入细胞质有了更深入的理解和控制，这是提高它们作用效果的关键步骤。
本综述提供了对当前内吞作用过程知识的更新概述；此外，本文还根据其报道的内化机制讨论了最常用于药物传递的细胞表面受体，并从最新的科学文献中举例说明了它们作为纳米载体靶标的应用。
对分子生物学细节的了解对于合理设计药物传递系统越来越必要。在这里，我们的目的是为读者提供一种尝试，将内吞作用机制的知识与识别合适的纳米载体目标（内化受体）联系起来。
要创建一个完整和连贯的内吞作用生物学图像，还有很多进展需要取得，但目前的知识已经允许确定大量可靶向的目标群体，以实现纳米载体的预定细胞内命运。
