Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.
BMC Bioinformatics. 2010 Jul 14;11:377. doi: 10.1186/1471-2105-11-377.
High throughput sequencing has become an increasingly important tool for biological research. However, the existing software systems for managing and processing these data have not provided the flexible infrastructure that research requires.
Existing software solutions provide static and well-established algorithms in a restrictive package. However as high throughput sequencing is a rapidly evolving field, such static approaches lack the ability to readily adopt the latest advances and techniques which are often required by researchers. We have used a loosely coupled, service-oriented infrastructure to develop SeqAdapt. This system streamlines data management and allows for rapid integration of novel algorithms. Our approach also allows computational biologists to focus on developing and applying new methods instead of writing boilerplate infrastructure code.
The system is based around the Addama service architecture and is available at our website as a demonstration web application, an installable single download and as a collection of individual customizable services.
高通量测序已成为生物学研究中越来越重要的工具。然而,现有的用于管理和处理这些数据的软件系统并没有提供研究所需的灵活基础架构。
现有的软件解决方案在一个受限制的包中提供静态且成熟的算法。然而,由于高通量测序是一个快速发展的领域,这种静态方法缺乏快速采用最新进展和技术的能力,而这些往往是研究人员所需要的。我们使用了一种松散耦合的面向服务的基础架构来开发 SeqAdapt。该系统简化了数据管理,并允许快速集成新算法。我们的方法还允许计算生物学家专注于开发和应用新方法,而不是编写样板基础设施代码。
该系统基于 Addama 服务架构,可在我们的网站上作为演示 Web 应用程序、可安装的单个下载以及作为一组可定制的单个服务获得。