Department of Veterinary Science and Microbiology, University of Arizona, 1117, East Lowell St., Tucson, AZ 85721, USA.
Future Microbiol. 2010 Jul;5(7):1109-23. doi: 10.2217/fmb.10.60.
Many Gram-positive spore-forming bacteria in the Firmicute phylum are important members of the human commensal microbiota, which, in rare cases, cause opportunistic infections. Other spore-formers, however, have evolved to become dedicated pathogens that can cause a striking variety of diseases. Despite variations in disease presentation, the etiologic agent is often the spore, with bacterially produced toxins playing a central role in the pathophysiology of infection. This review will focus on the specific diseases caused by spores of the Clostridia and Bacilli.
厚壁菌门中的许多革兰氏阳性产芽孢细菌是人类共生微生物群的重要成员，但在极少数情况下会引起机会性感染。然而，其他芽孢形成体已经进化为专门的病原体，可以引起各种不同的疾病。尽管疾病表现存在差异，但病原体通常是芽孢，细菌产生的毒素在感染的病理生理学中起着核心作用。本综述将重点介绍梭菌属和芽孢杆菌属芽孢引起的特定疾病。
