Endocrinology Division, Department of Medicine, McMaster University, Hamilton, ON, Canada.
J Endocrinol Invest. 2011 Jan;34(1):e12-5. doi: 10.1007/BF03346703. Epub 2010 Jul 13.
Adipose tissue has been suggested to influence bone density and metabolism through the effect of some adipokines. However, whether adiponectin and visfatin may correlate with bone metabolism is still unclear.
The aim of this study was to investigate the relationship of adiponectin and visfatin with bone density in patients with metabolic syndrome (MS).
We enroled 72 consecutive patients with MS (25 males, 47 females; mean age 58.14±11 yr) and 40 control subjects.
Plasma adiponectin and visfatin levels were measured. Bone mineral density (BMD) was assessed by dual energy X-ray absorptiometry (DXA) at the level of lumbar spine L2-L4 (BMD L2-L4) and femoral neck (BMD-Fn).
MS patients had higher plasma visfatin and lower adiponectin levels than controls, (p<0.01 for both). Adiponectin was negatively correlated with BMD-Fn and BMD L2-L4 (r=-0.20, r=-0.24, respectively; p<0.05 for both) whereas plasma visfatin levels were positively correlated to BMD L2-L4 only in men (r=0.44; p<0.05).
Our study shows that adiponectin and visfatin are oppositely associated with BMD. Although the mechanisms behind these correlations are unclear, a modulation of bone metabolism by these adipokines can be suggested.
脂肪组织通过某些脂肪因子的作用被认为会影响骨密度和代谢。然而，脂联素和内脂素是否与骨代谢相关仍不清楚。
本研究旨在探讨代谢综合征（MS）患者脂联素和内脂素与骨密度的关系。
我们招募了 72 例连续的 MS 患者（25 名男性，47 名女性；平均年龄 58.14±11 岁）和 40 名对照受试者。
测量血浆脂联素和内脂素水平。采用双能 X 线吸收法（DXA）测定腰椎 L2-L4 水平（L2-L4 骨密度，BMD L2-L4）和股骨颈（BMD-Fn）的骨密度。
MS 患者的血浆内脂素水平高于对照组，脂联素水平低于对照组（均为 p<0.01）。脂联素与 BMD-Fn 和 BMD L2-L4 呈负相关（r=-0.20，r=-0.24；均为 p<0.05），而血浆内脂素水平仅与男性的 BMD L2-L4 呈正相关（r=0.44；p<0.05）。
我们的研究表明，脂联素和内脂素与 BMD 呈相反的相关性。尽管这些相关性的机制尚不清楚，但可以推测这些脂肪因子对骨代谢有调节作用。
