Department of HIV, Guys and St Thomas' NHS Trust/ Kings College London, St Thomas' Hospital, London, UK.
AIDS. 2010 Sep 24;24(15):2397-401. doi: 10.1097/QAD.0b013e32833cbb5b.
To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK.
Observational study.
MSM diagnosed with HIV-1 infection from 1980-2007, with HIV genotype held in the UK HIV Drug Resistance Database were identified. Protease and reverse transcriptase sequences were collected and viral clade determined using the REGA algorithm. Associations between demographic variables and subtype were analysed using logistic regression.
The prevalence of non-B HIV-1 infection amongst MSM in the UK was 5.4% (437/8058). In the UK this increased with year of diagnosis from pre1996 to 2002, and has subsequently remained relatively stable at around 7-9% after 2002, with a recent increase in 2007 to 13%. Multivariate analysis showed that acquisition of non-B HIV-1 infection was independently associated with later year of HIV diagnosis (P < 0.001), black ethnicity (P < 0.001) and non-European country of birth (P = 0.01). Age was also associated with subtype with individuals aged 25-39 years being less likely to have non-B virus than those aged less than 25 years (P = 0.01). Restricting the analysis to white men born in the UK, the association between subtype and year of diagnosis remained statistically significant (P < 0.001), as did the association with age (P < 0.001).
The number of MSM in the UK infected with non-B clade HIV-1 is increasing, suggesting that the sociodemographic boundaries between HIV-1 viral subtypes globally are diminishing. Should viral subtypes be relevant to clinical disease progression or vaccine design, the changing pattern of distribution will need to be taken into account.
描述英国男男性行为者（MSM）中感染非 B 型 HIV-1 亚型的频率和风险因素。
观察性研究。
确定了 1980-2007 年在英国诊断出 HIV-1 感染的 MSM，并在英国 HIV 耐药数据库中保存了 HIV 基因型。收集蛋白酶和逆转录酶序列，并使用 REGA 算法确定病毒谱系。使用逻辑回归分析人口统计学变量与亚型之间的关系。
英国 MSM 中非 B 型 HIV-1 感染的患病率为 5.4%（437/8058）。在英国，这一比例随着诊断年份的增加，从 1996 年前到 2002 年有所增加，此后在 2002 年后相对稳定在 7-9%左右，2007 年略有增加至 13%。多变量分析表明，感染非 B 型 HIV-1 与 HIV 诊断的较晚年份（P<0.001）、黑人种族（P<0.001）和非欧洲国家出生（P=0.01）独立相关。年龄也与亚型相关，25-39 岁的个体感染非 B 型病毒的可能性低于 25 岁以下的个体（P=0.01）。将分析仅限于在英国出生的白人男性，诊断年份与亚型之间的关联仍然具有统计学意义（P<0.001），年龄与亚型之间的关联也是如此（P<0.001）。
感染非 B 谱系 HIV-1 的英国 MSM 人数正在增加，这表明全球 HIV-1 病毒亚型的社会人口学界限正在缩小。如果病毒亚型与临床疾病进展或疫苗设计有关，那么需要考虑到分布模式的变化。
