AIDS. 2014 Mar 13;28(5):773-80. doi: 10.1097/QAD.0000000000000119.
HIV-1 is typically categorized by genetically distinct viral subtypes. Viral subtypes are usually compartmentalized by ethnicity and transmission group and, thus, convey important epidemiological information, as well as possibly influencing the rate of disease progression. We aim to describe the prevalence and time trends of subtypes observed among key populations living with HIV-1 in the UK.
Analyses of reverse transcriptase and protease sequences generated from HIV-1-positive antiretroviral-naive patients as part of routine resistance testing between 2002 and 2010 in all public health and NHS laboratories in the UK.
Subtype was assigned centrally using the SCUEAL algorithm. Subtyping results were combined with data from the UK Collaborative HIV Cohort Study and the UK HIV and AIDS Reporting System. Analyses adjusted for the number of national HIV-1 diagnoses made each year within demographic subgroups. Viral subtypes were described overall, over time and by demographic subgroup.
Subtype B diagnoses (39.9%) have remained stable since 2005, whereas subtype C diagnoses (34.3%) were found to decline in prevalence from 2004. Across most demographic subgroups, the prevalence of non-B non-C subtypes has increased over time, in particular novel recombinant forms (9.9%), subtype G (2.7%), and CRF01 AE (2.0%).
HIV-1 subtypes are increasingly represented across all demographic subgroups and this could be evidence of sexual mixing. Between 2002 and 2010, the prevalence of novel recombinant forms has increased in all demographic subgroups. This increasing genetic diversity and the effect of subtype on disease progression may impact future HIV-1 treatment and prevention.
HIV-1通常按基因上不同的病毒亚型进行分类。病毒亚型通常按种族和传播群体进行区分，因此，其传递着重要的流行病学信息，还可能影响疾病进展速度。我们旨在描述在英国感染HIV-1的重点人群中观察到的亚型流行情况和时间趋势。
对2002年至2010年期间在英国所有公共卫生和国民保健服务实验室作为常规耐药性检测一部分从HIV-1阳性且未接受过抗逆转录病毒治疗的患者中生成的逆转录酶和蛋白酶序列进行分析。
使用SCUEAL算法在中心进行亚型分类。将亚型分类结果与英国HIV协作队列研究和英国HIV与艾滋病报告系统的数据相结合。分析针对各人口亚组内每年全国HIV-1诊断病例数进行了调整。总体、按时间以及按人口亚组对病毒亚型进行了描述。
自2005年以来，B亚型诊断病例（39.9%）一直保持稳定，而C亚型诊断病例（34.3%）的流行率自2004年起呈下降趋势。在大多数人口亚组中，非B非C亚型的流行率随时间增加，尤其是新型重组形式（9.9%）、G亚型（2.7%）和CRF01_AE（2.0%）。
HIV-1亚型在所有人口亚组中的占比越来越高，这可能是性接触混合的证据。在2002年至2010年期间，新型重组形式在所有人口亚组中的流行率均有所增加。这种不断增加的基因多样性以及亚型对疾病进展的影响可能会对未来HIV-1的治疗和预防产生影响。
