Dzhavad-Zade M D, Agaev M M, Fel'dman V M, Torosian A Ts, Akhmedova L A
Urol Nefrol (Mosk). 1991 Mar-Apr(2):3-8.
365 females followed up for 4-6 years who had new-onset or repeated nephropathy at pregnancy (NP) showed during the II and III trimester impaired humoral immunity evident from elevated levels of IgA, IgM and CIC. NP relapses at repeated pregnancies occurred in 89%, residual manifestations of the disease in 45% of the examinees. Postnatal immunological studies of women with previous NP but no clinical signs of it at the time of examination still continued to demonstrate alterations in cellular and humoral immunity. Glomerular filtration rate in response to water loading indicated their reduced renal reserves. It is suggested that in nonpregnant females with an NP history this disease runs a subclinical course which may be considered a remission. This dictates certain diagnostic and therapeutic measures that should be taken to prevent complications. NP patients follow-up and regular check-ups help to decrease relevant risk at subsequent pregnancies.
对365名在孕期出现新发或复发性肾病（NP）并随访4至6年的女性进行研究，结果显示，在妊娠中期和晚期，她们的体液免疫受损，表现为IgA、IgM和循环免疫复合物（CIC）水平升高。89%的女性在再次怀孕时出现NP复发，45%的受检者有疾病残留表现。对既往有NP但检查时无临床症状的女性进行产后免疫学研究，仍发现其细胞免疫和体液免疫存在改变。水负荷试验后的肾小球滤过率表明她们的肾脏储备功能降低。建议有NP病史的非妊娠女性，该疾病呈亚临床病程，可视为缓解期。这决定了应采取某些诊断和治疗措施以预防并发症。对NP患者进行随访和定期检查有助于降低后续妊娠的相关风险。
