San Francisco VA Medical Center, University of California, San Francisco, CA 94121, USA.
J Addict Dis. 2010 Jul;29(3):359-69. doi: 10.1080/10550887.2010.489449.
Comorbid medical illness is common in patients with chronic hepatitis C (HCV) infection and in methadone treatment (MMT) patients, yet little is known about the impact of medical illness on HCV treatment eligibility. Medical illness and HCV treatment eligibility were compared in a case-control study of 80 MMT patients entering an HCV treatment trial and 80 matched non-MMT patients entering HCV treatment in a gastroenterology clinic. 91% of MMT and 85% of non-MMT patients had chronic medical conditions. Despite similar medical severity ratings, a significantly higher proportion (77%) of non-MMT patients were eligible for HCV treatment than were MMT patients (56%) (p<.01). Specific comorbid medical and psychiatric illness led to ineligibility in only 18% of MMT and 16% of non-MMT patients. However, failure to complete the medical evaluation process was significantly (p<.001) more likely to cause ineligibility among MMT patients (19%) than non-MMT patients (0%).
合并症 在慢性丙型肝炎（HCV）感染和接受美沙酮治疗（MMT）的患者中很常见，但对于合并症对 HCV 治疗资格的影响知之甚少。在一项 80 例 MMT 患者和 80 例匹配的非 MMT 患者进入 HCV 治疗试验的病例对照研究中，比较了合并症和 HCV 治疗资格。91%的 MMT 和 85%的非 MMT 患者患有慢性疾病。尽管合并症严重程度相似，但非 MMT 患者中 HCV 治疗合格的比例（77%）明显高于 MMT 患者（56%）（p<.01）。只有 18%的 MMT 和 16%的非 MMT 患者因特定的合并症医疗和精神疾病而不合格。然而，未能完成医学评估过程导致 MMT 患者（19%）而非非 MMT 患者（0%）不合格的可能性显著更高（p<.001）。
