Laboratório de Investigação em Dermatologia e Imunodeficiências - LIM 56, Faculdade de Medicina da Universidade de São Paulo, Instituto de Medicina Tropical - prédio II, Av. Dr. Enéas de Carvalho Aguiar, 470 - 3o andar, CEP 05403-05000, São Paulo, Brazil.
Immunotherapy. 2009 Nov;1(6):1039-51. doi: 10.2217/imt.09.68.
Knowledge concerning the immunology of dendritic cells (DCs) accumulated over the last few decades and the development of methodologies to generate and manipulate these cells in vitro has made their therapeutic application a reality. Currently, clinical protocols for DC-based therapeutic vaccine in HIV-infected individuals show that it is a safe and promising approach. Concomitantly, important advances continue to be made in the development of methodologies to optimize DC acquisition, as well as the selection of safe, immunogenic HIV antigens and the evaluation of immune response in treated individuals.
过去几十年中，人们对树突状细胞（DC）的免疫学特性的认识不断加深，同时也开发出了在体外生成和操作这些细胞的方法，这使得它们的治疗应用成为可能。目前，针对 HIV 感染者的基于 DC 的治疗性疫苗的临床方案表明，这是一种安全且有前途的方法。同时，在优化 DC 获取方法、选择安全免疫原性 HIV 抗原以及评估治疗个体的免疫反应方面，也取得了重要进展。
