Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Erlangen, Germany.
Clin Oral Implants Res. 2010 Jul;21(7):726-34. doi: 10.1111/j.1600-0501.2009.01904.x.
The early stages of peri-implant bone formation play an essential role in the osseointegration and long-term success of dental implants. By incorporating bioactive coatings, this biofunctionalization of implant surfaces may enhance the attachment of the implant to the surrounding bone and stimulate bone regeneration.
To demonstrate faster osseointegration, the surfaces of dental implants were grit-blasted and acid-etched. They were then coated with hydroxyapatite (HA) and experimental implants were further coated with a biomimetic active peptide (P-15) in one of two concentrations. These biofunctionalized samples and controls with no peptide were placed in the forehead region of 12 adult pigs. Six animals were evaluated for a period of 14 or 30 days.
Histomorphometric analysis demonstrated that the implants with the high concentration of P-15 had significantly higher percentage of bone-to-implant contact (BIC) at 14 (P=0.018) and 30 (P=0.015) days compared with the other groups. Both concentrations of P-15 showed increased peri-implant bone density compared to the control group at 30 days.
Biofunctionalization of the implant surface with a biomimetic active peptide leads to significantly increased BIC rates at 14 and 30 days and higher peri-implant bone density at 30 days.
种植体周围骨形成的早期阶段对种植体的骨整合和长期成功起着至关重要的作用。通过引入生物活性涂层，可以对种植体表面进行生物功能化，从而增强种植体与周围骨的附着，并刺激骨再生。
为了实现更快的骨整合，对牙种植体表面进行了喷砂酸蚀处理。然后，它们被羟基磷灰石（HA）涂层覆盖，实验性种植体进一步用两种浓度之一的仿生活性肽（P-15）进行涂层。这些生物功能化样本和没有肽的对照样本被放置在 12 头成年猪的额部区域。其中 6 只动物在 14 或 30 天进行评估。
组织形态计量学分析表明，高浓度 P-15 的种植体在 14 天（P=0.018）和 30 天（P=0.015）时的骨-种植体接触率（BIC）明显更高。两种浓度的 P-15 在 30 天时与对照组相比，均显示出更高的种植体周围骨密度。
用仿生活性肽对种植体表面进行生物功能化处理可使 14 天和 30 天的 BIC 率显著增加，30 天的种植体周围骨密度更高。
