Department of Clinical Sciences, College of Dentistry, Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE.
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Jordan, Amman, Jordan.
Clin Oral Investig. 2024 Oct 11;28(11):592. doi: 10.1007/s00784-024-05958-y.
Bioactive surface modifications have been proposed to enhance osseointegration and longevity of dental implants. This study aimed to systematically review and perform a meta-analysis on the effectiveness of various bioactive coatings in promoting bone integration and improving implant longevity.
A systematic review was conducted, including studies that investigated bioactive surface modifications on titanium dental implants. Outcomes of interest were bone-to-implant contact (BIC) and implant longevity over a 30-day period. Data were extracted and analyzed using RevMan 5 (version 5.4.1), with forest plots generated to represent the mean difference (MD) and 95% confidence intervals (CI) under a random effects model.
The meta-analysis showed a significant improvement in BIC for surface-modified implants, with an overall MD of 7.29 (95% CI [2.94, 11.65]). Heterogeneity analysis indicated moderate heterogeneity (Tau² = 18.57, Chi² = 16.08, df = 8, P = 0.04, I² = 50%). The test for overall effect yielded Z = 3.28 (P = 0.001). For implant longevity, the overall MD was 7.52 (95% CI [3.18, 11.85]), with moderate heterogeneity (Tau² = 17.28, Chi² = 14.95, df = 8, P = 0.06, I² = 47%). The test for overall effect yielded Z = 3.40 (P = 0.0007).
Bioactive surface changes significantly improved osseointegration and lifespan of dental implants. Collagen-based coatings consistently encouraged early bone integration, while BMP-2 combinations were effective for osseointegration. Optimizing bioactive agent doses and combinations was critical for achieving desired outcomes.
生物活性表面改性被提议用于增强牙种植体的骨整合和延长其使用寿命。本研究旨在系统回顾并进行荟萃分析，以评估各种生物活性涂层在促进骨整合和改善种植体寿命方面的有效性。
进行了系统回顾，包括研究生物活性表面改性对钛牙种植体的影响。感兴趣的结果是 30 天内的骨-种植体接触（BIC）和种植体寿命。使用 RevMan 5（版本 5.4.1）提取和分析数据，使用森林图表示随机效应模型下的平均差异（MD）和 95%置信区间（CI）。
荟萃分析显示，表面改性种植体的 BIC 显著改善，总体 MD 为 7.29（95%CI[2.94,11.65]）。异质性分析表明存在中度异质性（Tau²=18.57，Chi²=16.08，df=8，P=0.04，I²=50%）。总体效应检验的 Z 值为 3.28（P=0.001）。对于种植体寿命，总体 MD 为 7.52（95%CI[3.18,11.85]），存在中度异质性（Tau²=17.28，Chi²=14.95，df=8，P=0.06，I²=47%）。总体效应检验的 Z 值为 3.40（P=0.0007）。
生物活性表面改变显著改善了牙种植体的骨整合和寿命。基于胶原蛋白的涂层可持续促进早期骨整合，而 BMP-2 联合使用则对骨整合有效。优化生物活性剂剂量和组合对实现预期效果至关重要。
