Sequeira Peña G A, Herrmann D, Vogt K H, Jäger L
Institut für Klinische Immunologie, Medizinischen Fakultät, Friedrich-Schiller-Universität Jena, Bundesrepublik Deutschland.
Allerg Immunol (Leipz). 1991;37(1):37-45.
In 353 sera (from healthy donors as well as patients suffering from rheumatoid arthritis, systemic lupus erythematosus, hepatitis, malignant melanoma) circulating immune complexes were determined by C1q-binding test and a C1q solid-phase ELISA. Using peroxidase-labelled antibodies (from rabbit) against human mu-, gamma-, and alpha-heavy chains, the immunoglobulin classes in the complexes were determined. In rheumatoid arthritis, immune complexes contain IgM more frequently (41.5%) than in systemic lupus erythematosus (10%). Immune complexes containing only IgA as immunoglobulin were found in 24 cases. Our results including binding experiments with chemically aggregated IgA suggest, that the binding of C1q to IgA is not necessarily followed by classical complement activation.
在353份血清（来自健康供体以及患有类风湿性关节炎、系统性红斑狼疮、肝炎、恶性黑色素瘤的患者）中，通过C1q结合试验和C1q固相酶联免疫吸附测定法测定循环免疫复合物。使用针对人μ、γ和α重链的过氧化物酶标记抗体（兔源），测定复合物中的免疫球蛋白类别。在类风湿性关节炎中，免疫复合物中IgM的出现频率（41.5%）高于系统性红斑狼疮（10%）。在24例病例中发现仅含有IgA作为免疫球蛋白的免疫复合物。我们的结果包括与化学聚集IgA的结合实验表明，C1q与IgA的结合不一定会引发经典的补体激活。
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