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[六亚甲基双乙酰胺对胚胎癌细胞分化的影响]

[Effects of hexamethylenebisacetamide on the differentiation of embryonal carcinoma cells].

作者信息

Jakob H, Dubois P, Eisen H, Jacob F

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Jan;286(1):109-11.

PMID:206377
Abstract

HMBA induces differentiation in the whole population of some multipotential embryonic carcinoma cells. Morphological, biochemical and immunological changes can be observed even after short treatment. The cells lose the embryonal F9 antigen without acquiring H-2 antigens.

摘要

六亚甲基双乙酰胺可诱导部分多能胚胎癌细胞群体发生分化。即使经过短期处理，也能观察到形态、生化和免疫学变化。细胞失去胚胎F9抗原，且未获得H-2抗原。

相似文献

1
[Effects of hexamethylenebisacetamide on the differentiation of embryonal carcinoma cells].[六亚甲基双乙酰胺对胚胎癌细胞分化的影响]
C R Acad Hebd Seances Acad Sci D. 1978 Jan;286(1):109-11.
2
Differentiation-defective mutants of mouse embryonal carcinoma cells: response to hexamethylenebisacetamide and retinoic acid.小鼠胚胎癌细胞分化缺陷型突变体：对六亚甲基双乙酰胺和视黄酸的反应。
Dev Biol. 1983 Apr;96(2):416-26. doi: 10.1016/0012-1606(83)90179-3.
3
Complementation analyses of differentiation-defective embryonal carcinoma cells.分化缺陷型胚胎癌细胞的互补分析
Dev Biol. 1984 Jun;103(2):399-408. doi: 10.1016/0012-1606(84)90327-0.
4
Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide.在由六亚甲基双乙酰胺诱导分化的胚胎癌细胞中，原肌球蛋白的合成伴随着肌动蛋白丝的形成。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1891-5. doi: 10.1073/pnas.76.4.1891.
5
Different patterns of glycolipid antigens are expressed following differentiation of TERA-2 human embryonal carcinoma cells induced by retinoic acid, hexamethylene bisacetamide (HMBA) or bromodeoxyuridine (BUdR).视黄酸、六亚甲基双乙酰胺（HMBA）或溴脱氧尿苷（BUdR）诱导TERA-2人胚胎癌细胞分化后，会表达不同模式的糖脂抗原。
Differentiation. 1990 Apr;43(2):131-8. doi: 10.1111/j.1432-0436.1990.tb00439.x.
6
Stimulation of the clonal growth and differentiation of feeder layer dependent mouse embryonal carcinoma cells by beta-mercaptoethanol.
Differentiation. 1978;11(3):149-55. doi: 10.1111/j.1432-0436.1978.tb00978.x.
7
Inducer-dependent phenotypic divergence in an embryonal-carcinoma cell line.胚胎癌细胞系中诱导剂依赖性表型分化
Differentiation. 1984;27(3):236-42. doi: 10.1111/j.1432-0436.1984.tb01434.x.
8
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.通过抑制多胺合成诱导F9胚胎癌细胞分化
Eur J Cell Biol. 1985 Sep;38(2):335-43.
9
[Fundamental studies on differentiation inducers using a human embryonal carcinoma model].
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Oct;43(10):1303-9.
10
[Phenotype transition of B 7-2 embryonal carcinoma cells during induced differentiation with hexamethylenebisacetamide].[六亚甲基双乙酰胺诱导分化过程中B 7-2胚胎癌细胞的表型转变]
Shi Yan Sheng Wu Xue Bao. 1986 Sep;19(3):369-79.

引用本文的文献

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Specific differentiation of mesenchymal stem cells by small molecules.小分子诱导间充质干细胞的特异性分化
Am J Stem Cells. 2011 Aug 18;1(1):22-30. Print 2012.
2
Surface antigens of human embryonic stem cells: changes upon differentiation in culture.人类胚胎干细胞的表面抗原：培养分化过程中的变化
J Anat. 2002 Mar;200(Pt 3):249-58. doi: 10.1046/j.1469-7580.2002.00030.x.
3
From teratocarcinomas to embryonic stem cells.从畸胎癌到胚胎干细胞。
Philos Trans R Soc Lond B Biol Sci. 2002 Apr 29;357(1420):405-17. doi: 10.1098/rstb.2002.1058.
4
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.小鼠体内和体外细胞分化过程中DNA甲基化的变化。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2275-9. doi: 10.1073/pnas.81.8.2275.
5
Tumor viruses and early mouse embryos.肿瘤病毒与早期小鼠胚胎
Biochim Biophys Acta. 1982 Apr 29;651(2-3):105-41. doi: 10.1016/0304-419x(82)90009-9.
6
Serological identification and cellular distribution of three F9 antigen components.三种F9抗原成分的血清学鉴定及细胞分布
J Exp Med. 1980 Dec 1;152(6):1497-505. doi: 10.1084/jem.152.6.1497.
7
Sodium butyrate induces histone hyperacetylation and differentiation of murine embryonal carcinoma cells.丁酸钠可诱导小鼠胚胎癌细胞的组蛋白高度乙酰化和分化。
J Cell Biol. 1984 Feb;98(2):602-8. doi: 10.1083/jcb.98.2.602.
8
Chemically induced bidirectional differentiation of embryonal carcinoma cells in vitro.化学诱导胚胎癌细胞在体外的双向分化
Am J Pathol. 1979 Dec;97(3):563-84.
9
Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide.在由六亚甲基双乙酰胺诱导分化的胚胎癌细胞中，原肌球蛋白的合成伴随着肌动蛋白丝的形成。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1891-5. doi: 10.1073/pnas.76.4.1891.
10
Metabolic cooperation between mouse embryonal carcinoma cells and their differentiated derivatives.小鼠胚胎癌细胞与其分化衍生物之间的代谢合作。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3292-6. doi: 10.1073/pnas.75.7.3292.