Division of Rheumatology, Medicine III, Medical University of Vienna, General Hospital of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
J Autoimmun. 2010 Nov;35(3):269-75. doi: 10.1016/j.jaut.2010.06.018. Epub 2010 Jul 16.
The development of autoimmune diseases is characterized by the breakdown of mechanism(s) that are responsible for maintaining immunological tolerance against self-structures in the periphery. Several aberrations of immune cells have been described so far. Most recently quantitative and/or qualitative defects of T cells with the capacity to suppress or regulate the proliferation of effector T cells in vitro - subsequently termed regulatory T cells (Treg) - have been suggested to substantially contribute to the imbalance of peripheral tolerance and trigger the outbreak of autoimmune reactions. The aim of this article is to summarize current knowledge about pathomechanisms that are involved in the development of autoimmunity with a special emphasis on the role of Treg in patients with systemic lupus erythematosus (SLE).
自身免疫性疾病的发展以负责维持外周自身结构免疫耐受的机制（多个）的破坏为特征。迄今为止，已经描述了免疫细胞的多种异常。最近，体外具有抑制或调节效应 T 细胞增殖能力的 T 细胞的定量和/或定性缺陷 - 随后称为调节性 T 细胞（Treg） - 被认为对外周耐受的失衡有很大贡献，并引发自身免疫反应。本文的目的是总结目前关于自身免疫发展中涉及的病理机制的知识，特别强调 Treg 在系统性红斑狼疮（SLE）患者中的作用。
