家族性精神分裂症患者前扣带回皮质灰质减少：初步报告。
Reduced gray matter in the anterior cingulate gyrus in familial schizophrenia: a preliminary report.
机构信息
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
出版信息
Schizophr Res. 2010 Sep;122(1-3):81-4. doi: 10.1016/j.schres.2010.06.014. Epub 2010 Jul 16.
Abstract
Few brain imaging studies of schizophrenia involve samples with enhanced genetic homogeneity. We compared MRI volumetric data between individuals with 1q21-q23 linked familial schizophrenia associated with NOS1AP and their first and second degree unaffected relatives. We found significant gray matter reductions in the anterior cingulate gyrus in both affected individuals and their unaffected first degree relatives when compared with their unaffected second degree relatives. These results suggest that the changes are primarily due to genetic risk and not illness effects, and may represent an intermediate phenotype.
摘要
很少有涉及遗传同质性增强的精神分裂症脑影像学研究。我们比较了与 NOS1AP 相关的 1q21-q23 连锁家族性精神分裂症个体及其一级和二级无病亲属的 MRI 容积数据。与二级无病亲属相比，我们发现受影响个体及其一级无病亲属的前扣带回皮质灰质减少。这些结果表明，这些变化主要是由于遗传风险而不是疾病效应所致，并且可能代表一种中间表型。
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