Arday D R, Brundage J F, Gardner L I, Goldenbaum M, Wann F, Wright S
Department of Advanced Preventive Medicine Studies, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Am J Epidemiol. 1991 Jun 15;133(12):1210-9. doi: 10.1093/oxfordjournals.aje.a115833.
The authors conducted a population-based study to attempt to estimate the effect of human immunodeficiency virus type 1 (HIV-1) seropositivity on Armed Services Vocational Aptitude Battery test scores in otherwise healthy individuals with early HIV-1 infection. The Armed Services Vocational Aptitude Battery is a 10-test written multiple aptitude battery administered to all civilian applicants for military enlistment prior to serologic screening for HIV-1 antibodies. A total of 975,489 induction testing records containing both Armed Services Vocational Aptitude Battery and HIV-1 results from October 1985 through March 1987 were examined. An analysis data set (n = 7,698) was constructed by choosing five controls for each of the 1,283 HIV-1-positive cases, matched on five-digit ZIP code, and a multiple linear regression analysis was performed to control for demographic and other factors that might influence test scores. Years of education was the strongest predictor of test scores, raising an applicant's score on a composite test nearly 0.16 standard deviation per year. The HIV-1-positive effect on the composite score was -0.09 standard deviation (99% confidence interval -0.17 to -0.02). Separate regressions on each component test within the battery showed HIV-1 effects between -0.39 and +0.06 standard deviation. The two Armed Services Vocational Aptitude Battery component tests felt a priori to be the most sensitive to HIV-1-positive status showed the least decrease with seropositivity. Much of the variability in test scores was not predicted by either HIV-1 serostatus or the demographic and other factors included in the model. There appeared to be little evidence of a strong HIV-1 effect.
作者开展了一项基于人群的研究,试图评估1型人类免疫缺陷病毒(HIV-1)血清学阳性对早期HIV-1感染的健康个体的武装部队职业能力倾向测验(ASVAB)分数的影响。武装部队职业能力倾向测验是一项包含10个测试的书面多项能力倾向测验,在对所有应征入伍的平民申请者进行HIV-1抗体血清学筛查之前进行。研究人员检查了1985年10月至1987年3月期间共975,489份包含武装部队职业能力倾向测验和HIV-1检测结果的入伍测试记录。通过为1,283例HIV-1阳性病例中的每一例选择5名对照构建分析数据集(n = 7,698),这些对照按五位邮政编码进行匹配,并进行多元线性回归分析以控制可能影响测试分数的人口统计学和其他因素。受教育年限是测试分数的最强预测因素,每年使申请者在综合测试中的分数提高近0.16个标准差。HIV-1阳性对综合分数的影响为-0.09个标准差(99%置信区间为-0.17至-0.02)。对该测验中每个分项测试进行单独回归分析显示,HIV-1的影响在-0.39至+0.06个标准差之间。预先认为对HIV-1阳性状态最敏感的两项武装部队职业能力倾向测验分项测试,其分数随血清学阳性的下降幅度最小。测试分数的大部分变异性无法通过HIV-1血清学状态或模型中纳入的人口统计学及其他因素来预测。似乎几乎没有证据表明HIV-1有强烈影响。