两栖类晶状体再生的分子与细胞层面
Molecular and cellular aspects of amphibian lens regeneration.
机构信息
Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA.
出版信息
Prog Retin Eye Res. 2010 Nov;29(6):543-55. doi: 10.1016/j.preteyeres.2010.07.002. Epub 2010 Jul 16.
Abstract
Lens regeneration among vertebrates is basically restricted to some amphibians. The most notable cases are the ones that occur in premetamorphic frogs and in adult newts. Frogs and newts regenerate their lens in very different ways. In frogs the lens is regenerated by transdifferentiation of the cornea and is limited only to a time before metamorphosis. On the other hand, regeneration in newts is mediated by transdifferentiation of the pigment epithelial cells of the dorsal iris and is possible in adult animals as well. Thus, the study of both systems could provide important information about the process. Molecular tools have been developed in frogs and recently also in newts. Thus, the process has been studied at the molecular and cellular levels. A synthesis describing both systems was long due. In this review we describe the process in both Xenopus and the newt. The known molecular mechanisms are described and compared.
摘要
脊椎动物的晶状体再生基本上仅限于一些两栖动物。最值得注意的例子是发生在变态前青蛙和成年蝾螈中的情况。青蛙和蝾螈以非常不同的方式再生晶状体。在青蛙中，晶状体通过角膜的去分化来再生，并且仅在变态前的一段时间内受到限制。另一方面，蝾螈的晶状体再生是由背部虹膜的色素上皮细胞的去分化介导的，并且在成年动物中也是可能的。因此，对这两个系统的研究可以提供关于该过程的重要信息。在青蛙中已经开发了分子工具，最近在蝾螈中也开发了分子工具。因此，该过程已经在分子和细胞水平上进行了研究。对同时描述这两个系统的综述早就应该进行了。在这篇综述中，我们描述了非洲爪蟾和蝾螈中的这个过程。描述并比较了已知的分子机制。
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