Institut National de la Recherche Agronomique, Unité de Recherches Zootechniques, Domaine de Duclos, 97170 Prise d'eau PETIT-BOURG, Guadeloupe (FWI).
Vet Parasitol. 2010 Oct 11;173(1-2):85-92. doi: 10.1016/j.vetpar.2010.06.017. Epub 2010 Jun 26.
Three extracts (aqueous, methanolic and dichloromethane) of Manihot esculenta (Cassava) leaf were tested in vitro on four development stages of Haemonchus contortus using egg hatch assay (EHA), larval development assay (LDA), L3 migration inhibition assay (LMI) and adult worm motility assay (AWM). Compared to the negative control, significant effects (P<0.0001) were observed for the methanolic extract of leaf against larval development (57.6% +/-7.6), with a dose dependent effect. These results suggest that Cassava possess anthelmintic activity against H. contortus. The active principles responsible for the activity could be the terpenoids and condensed tannin compounds present in the leaf.
三种马钱科植物（木薯）叶提取物（水提物、甲醇提物和二氯甲烷提物），采用卵孵化试验（EHA）、幼虫发育试验（LDA）、L3 迁移抑制试验（LMI）和成虫运动抑制试验（AWM），对感染有捻转血矛线虫的四个发育阶段进行了体外测试。与阴性对照相比，叶甲醇提取物对幼虫发育（57.6% +/-7.6）具有显著作用（P<0.0001），具有剂量依赖性效应。这些结果表明，木薯具有抗捻转血矛线虫的驱虫活性。负责这种活性的活性物质可能是存在于叶片中的萜类化合物和缩合单宁化合物。
