• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

膳食胆固醇调节兔海马 CA1 锥体神经元的兴奋性。

Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons.

机构信息

Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States.

出版信息

Neurosci Lett. 2010 Aug 2;479(3):327-31. doi: 10.1016/j.neulet.2010.05.090.

DOI:10.1016/j.neulet.2010.05.090
PMID:20639007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3000631/
Abstract

Previous work has shown high dietary cholesterol can affect learning and memory including rabbit eyeblink conditioning and this effect may be due to increased membrane cholesterol and enhanced hippocampal amyloid beta production. This study investigated whether dietary cholesterol modulates rabbit hippocampal CA1 neuron membrane properties known to be involved in rabbit eyeblink conditioning. Whole-cell current clamp recordings in hippocampal neurons from rabbits fed 2 percent cholesterol or normal chow for 8 weeks revealed changes including decreased after-hyperpolarization amplitudes (AHPs) - an index of membrane excitability shown to be important for rabbit eyeblink conditioning. This index was reversed by adding copper to drinking water - a dietary manipulation that can retard rabbit eyeblink conditioning. Evidence of cholesterol effects on membrane excitability was provided by application of methyl-beta-cyclodextrin, a compound that reduces membrane cholesterol, which increased the excitability of hippocampal CA1 neurons.

摘要

先前的研究表明，高膳食胆固醇会影响学习和记忆，包括兔子眨眼条件反射，这种影响可能是由于膜胆固醇增加和海马淀粉样β生成增强所致。本研究探讨了膳食胆固醇是否会调节已知与兔子眨眼条件反射有关的兔子海马 CA1 神经元膜特性。在喂养 2%胆固醇或正常饲料 8 周的兔子的海马神经元中进行全细胞膜片钳记录显示，变化包括后超极化幅度（AHP）减小 - 这是膜兴奋性的一个指标，对于兔子眨眼条件反射很重要。向饮水中添加铜可逆转这一指标 - 这种饮食干预可以延缓兔子眨眼条件反射。胆固醇对膜兴奋性的影响的证据是通过应用甲基-β-环糊精提供的，这是一种可降低膜胆固醇的化合物，可增加海马 CA1 神经元的兴奋性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06b/3000631/d24bdc23218a/nihms212085f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06b/3000631/298065ef9a56/nihms212085f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06b/3000631/d24bdc23218a/nihms212085f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06b/3000631/298065ef9a56/nihms212085f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06b/3000631/d24bdc23218a/nihms212085f2.jpg

相似文献

1
Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons.膳食胆固醇调节兔海马 CA1 锥体神经元的兴奋性。
Neurosci Lett. 2010 Aug 2;479(3):327-31. doi: 10.1016/j.neulet.2010.05.090.
2
Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation.家兔CA3神经元兴奋性的短暂变化，其时间进程适合支持记忆巩固。
J Neurophysiol. 1996 Sep;76(3):1836-49. doi: 10.1152/jn.1996.76.3.1836.
3
Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons.肿瘤坏死因子-α改变兔海马神经元的电生理特性。
J Alzheimers Dis. 2019;68(3):1257-1271. doi: 10.3233/JAD-190043.
4
Memory-enhancing intra-basolateral amygdala clenbuterol infusion reduces post-burst afterhyperpolarizations in hippocampal CA1 pyramidal neurons following inhibitory avoidance learning.记忆增强型基底外侧杏仁核注入克伦特罗可减少抑制性回避学习后海马CA1锥体神经元爆发后超极化。
Neurobiol Learn Mem. 2015 Mar;119:34-41. doi: 10.1016/j.nlm.2014.12.004. Epub 2015 Jan 19.
5
Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning.痕迹性眨眼条件反射后老年兔CA1神经元兴奋性增加。
J Neurosci. 2000 Jul 15;20(14):5476-82. doi: 10.1523/JNEUROSCI.20-14-05476.2000.
6
ΔFosB Decreases Excitability of Dorsal Hippocampal CA1 Neurons.ΔFosB 降低背侧海马 CA1 神经元的兴奋性。
eNeuro. 2018 Aug 3;5(4). doi: 10.1523/ENEURO.0104-18.2018. eCollection 2018 Jul-Aug.
7
β-Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons.β-肾上腺素受体依赖性调制大鼠海马 CA1 锥体神经元中的中后超极化。
J Neurophysiol. 2019 Mar 1;121(3):773-784. doi: 10.1152/jn.00334.2018. Epub 2019 Jan 9.
8
Aging and learning-specific changes in single-neuron activity in CA1 hippocampus during rabbit trace eyeblink conditioning.家兔痕迹性眨眼条件反射过程中CA1海马区单神经元活动的衰老及学习特异性变化
J Neurophysiol. 2001 Oct;86(4):1839-57. doi: 10.1152/jn.2001.86.4.1839.
9
5-HT receptors increase the excitability of hippocampal CA1 pyramidal neurons by inhibiting the A-type potassium current.5-HT 受体通过抑制 A 型钾电流来增加海马 CA1 锥体神经元的兴奋性。
Neuropharmacology. 2020 Oct 15;177:108248. doi: 10.1016/j.neuropharm.2020.108248. Epub 2020 Jul 29.
10
Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms.质膜神经鞘磷脂水解通过鞘氨醇-1-磷酸介导的机制增加海马神经元兴奋性。
J Neurochem. 2010 Jul;114(2):430-9. doi: 10.1111/j.1471-4159.2010.06779.x. Epub 2010 Apr 29.

引用本文的文献

1
Xylooligosaccharides and aerobic training regulate metabolism and behavior in rats with streptozotocin-induced type 1 diabetes.低聚木糖与有氧运动训练对链脲佐菌素诱导的1型糖尿病大鼠的代谢及行为具有调节作用。
Open Med (Wars). 2022 Oct 18;17(1):1632-1644. doi: 10.1515/med-2022-0579. eCollection 2022.
2
Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.大鼠小脑浦肯野细胞层周细胞网络破坏可改变眨眼条件反射和神经元电生理。
Neurobiol Learn Mem. 2021 Jan;177:107358. doi: 10.1016/j.nlm.2020.107358. Epub 2020 Dec 4.
3
Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons.

本文引用的文献

1
Cholesterol and ion channels.胆固醇与离子通道。
Subcell Biochem. 2010;51:509-49. doi: 10.1007/978-90-481-8622-8_19.
2
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice.记忆缺陷与中年小鼠调节神经元兴奋性的能力受损有关。
Learn Mem. 2009 May 23;16(6):362-6. doi: 10.1101/lm.1365609. Print 2009 Jun.
3
The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning.在海马神经元中，快速和慢速超极化后电位受到衰老和学习的差异性调节。
肿瘤坏死因子-α改变兔海马神经元的电生理特性。
J Alzheimers Dis. 2019;68(3):1257-1271. doi: 10.3233/JAD-190043.
4
Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning.在获得眨眼条件反射过程中大鼠小脑深部核团投射神经元膜特性的变化。
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9419-E9428. doi: 10.1073/pnas.1808539115. Epub 2018 Aug 28.
5
Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.胆固醇和酒精对神经元 G 蛋白门控内向整流钾 (GIRK) 通道的双重激活。
Sci Rep. 2017 Jul 4;7(1):4592. doi: 10.1038/s41598-017-04681-x.
6
bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles.bSUM：一种珠子支持的单层膜系统，有助于膜蛋白单向插入巨型囊泡。
J Gen Physiol. 2016 Jan;147(1):77-93. doi: 10.1085/jgp.201511448.
7
The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.海马损伤对痕迹眨眼条件反射及前脑-小脑相互作用的影响。
Behav Neurosci. 2015 Aug;129(4):512-22. doi: 10.1037/bne0000061.
8
Dietary cholesterol concentration affects synaptic plasticity and dendrite spine morphology of rabbit hippocampal neurons.饮食中的胆固醇浓度会影响兔海马神经元的突触可塑性和树突棘形态。
Brain Res. 2015 Oct 5;1622:350-60. doi: 10.1016/j.brainres.2015.06.049. Epub 2015 Jul 16.
9
Role of membrane biophysics in Alzheimer's-related cell pathways.膜生物物理学在阿尔茨海默病相关细胞通路中的作用。
Front Neurosci. 2015 May 27;9:186. doi: 10.3389/fnins.2015.00186. eCollection 2015.
10
Maturation of membrane properties of neurons in the rat deep cerebellar nuclei.大鼠小脑深部核团神经元膜特性的成熟
Dev Neurobiol. 2014 Dec;74(12):1268-76. doi: 10.1002/dneu.22203. Epub 2014 Jun 26.
J Neurosci. 2009 Apr 15;29(15):4750-5. doi: 10.1523/JNEUROSCI.0384-09.2009.
4
The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels.细胞胆固醇和细胞骨架在IK1与大电导钙激活钾通道相互作用中的作用。
Am J Physiol Cell Physiol. 2009 Apr;296(4):C878-88. doi: 10.1152/ajpcell.00438.2008. Epub 2009 Jan 28.
5
The BK-mediated fAHP is modulated by learning a hippocampus-dependent task.BK介导的迟发性外向电流通过学习海马依赖性任务受到调节。
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15154-9. doi: 10.1073/pnas.0805855105. Epub 2008 Sep 17.
6
Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele.在没有载脂蛋白E4等位基因的高龄受试者中，更好的记忆功能与更高的总胆固醇和低密度脂蛋白胆固醇水平相关。
Am J Geriatr Psychiatry. 2008 Sep;16(9):781-5. doi: 10.1097/JGP.0b013e3181812790.
7
Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat.饱和脂肪和高胆固醇饮食对中年大鼠记忆及海马形态的影响。
J Alzheimers Dis. 2008 Jun;14(2):133-45. doi: 10.3233/jad-2008-14202.
8
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels.BK和Shaker钾通道电压感受器中的一个细胞外铜离子结合位点。
J Gen Physiol. 2008 May;131(5):483-502. doi: 10.1085/jgp.200809980.
9
Effects of cholesterol levels on the excitability of rat hippocampal neurons.胆固醇水平对大鼠海马神经元兴奋性的影响。
Mol Membr Biol. 2008 Apr;25(3):216-23. doi: 10.1080/09687680701805541.
10
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.高胆固醇诱导的神经炎症和淀粉样前体蛋白加工与小鼠工作记忆丧失相关。
J Neurochem. 2008 Jul;106(1):475-85. doi: 10.1111/j.1471-4159.2008.05415.x. Epub 2008 Jul 1.