Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
IEEE Trans Biomed Eng. 2010 Oct;57(10):2568-71. doi: 10.1109/TBME.2010.2059025. Epub 2010 Jul 15.
Multispectral transillumination imaging is a promising modality for noninvasive imaging of living tissue. Multispectral Nevoscope imaging is directed toward the imaging of skin lesions for the detection and characterization of skin cancers through the volumetric analysis of selected chromophores, such as melanin, oxy-, and deoxyhemoglobin. In this letter, we present a novel method of recovering depth-dependent measurements from transillumination images obtained through the Nevoscope. A method for estimating the depth-dependent point spread function is presented and used in recovering multispectral transillumination images of a skin phantom or lesion through blind deconvolution. A method for ratiometric analysis for the quantification of oxy- and deoxyhemoglobin is then presented and evaluated on a skin phantom. The presented methods would allow reliable quantitative analysis of multispectral Nevoscope images for early detection of angiogenesis leading to early diagnosis of skin cancers.
多光谱透射成像是一种有前途的无创活体组织成像方式。多光谱 Nevoscope 成像旨在通过对选定的发色团（如黑色素、氧合和脱氧血红蛋白）进行体积分析，对皮肤病变进行成像，以检测和表征皮肤癌。在这封信中，我们提出了一种从 Nevoscope 获得的透射图像中恢复深度相关测量值的新方法。提出了一种估计深度相关点扩散函数的方法，并将其用于通过盲目反卷积恢复皮肤仿体或病变的多光谱透射图像。然后提出了一种用于定量分析氧合和脱氧血红蛋白的比率分析方法，并在皮肤仿体上进行了评估。所提出的方法将允许对多光谱 Nevoscope 图像进行可靠的定量分析，以早期检测导致皮肤癌早期诊断的血管生成。
