Dhawan Atam P, D'Alessandro Brian, Patwardhan Sachin, Mullani Nizar
Department of Electrical & Computer Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:5352-5. doi: 10.1109/IEMBS.2009.5334045.
Optical imaging of skin-lesions for early detection and management of the most fatal skin-cancer malignant melanoma is of significant interest in mass screening of skin-lesions with high-risk population. Surface illumination based optical imaging methods such as epiluminescence light microscopy (ELM) through "Dermascopy" has shown a significant potential in improving early diagnosis of malignant melanomas. Limitations of surface reflectance based imaging systems have been realized in analyzing images for important vascular and depth dependent information. We have developed a novel optical imaging system, the Nevoscope, that uses multispectral transillumination as to provide images of skin-lesions showing sub-surface pigmentation as well as vascular architecture based blood volume information. This paper presents multispectral Nevoscope transillumination method to compare and analyze ratiometric measurements to epiluminescence imaging for its ability to discriminate malignant melanomas from dysplastic nevi and other normal skin-lesions.
对最致命的皮肤癌——恶性黑色素瘤进行早期检测和管理的皮肤病变光学成像，在对高危人群进行皮肤病变大规模筛查中具有重大意义。基于表面照明的光学成像方法，如通过“皮肤镜检查”的落射光显微镜（ELM），在改善恶性黑色素瘤的早期诊断方面已显示出巨大潜力。基于表面反射的成像系统在分析重要的血管和深度相关信息的图像时存在局限性。我们开发了一种新型光学成像系统——痣镜，它利用多光谱透照来提供皮肤病变图像，显示皮下色素沉着以及基于血管结构的血容量信息。本文介绍了多光谱痣镜透照方法，以比较和分析比率测量与落射光成像，评估其区分发育异常痣和其他正常皮肤病变与恶性黑色素瘤的能力。
